PDB
7DFL
Resolution
3.3 Å
Released
March 31, 2021
Receptor
H1
Class
A
Species
Homo sapiens
Ligand
histamine
Function
Agonist
Reference
10.1038/S41467-021-22427-2

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
histamine D107 3.32x32 TM3 polar (charge-assisted hydrogen bond)
histamine Y108 3.33x33 TM3 Van der Waals
histamine Y108 3.33x33 TM3 hydrophobic
histamine S111 3.36x36 TM3 Van der Waals
histamine T112 3.37x37 TM3 Van der Waals
histamine T112 3.37x37 TM3 polar (hydrogen bond)
histamine N198 5.46x461 TM5 polar (hydrogen bond)
histamine Y431 6.51x51 TM6 polar (hydrogen bond)
histamine Y431 6.51x51 TM6 aromatic (face-to-edge)
histamine Y431 6.51x51 TM6 polar (hydrogen bond)
histamine F432 6.52x52 TM6 aromatic (face-to-edge)
histamine F432 6.52x52 TM6 Van der Waals
histamine I454 7.39x38 TM7 Van der Waals
histamine Y458 7.43x42 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 R K L H ICL1ECL1 S K W S L ECL1ICL2 P L R Y L K Y R ICL2ECL2 W N H F M Q Q T S V R R E D K C E T D F Y D ECL2ICL3 R S L P S F S E I K L R P E N P K G D A K K P G K E S P W E V L K R K P K D A G G G S V L K S P S Q T P K E M K S P V V F S Q E D D R E V D K L Y C F P L D I V H M Q A A A E G S S R D Y V A V N R S H G Q L K T D E Q G L N T H G A S E I S E D Q M L G D S Q S F S R T D S D T T T E T A P G K G K L R S G S N T G L D Y I K F T W K R L R S H S R Q Y V S ICL3ECL3 K N C C ECL3N-term M S L P N S S C L L E D K M C E G N K T T M A S P Q L M N-termC-term I R S C-term P L V V V L S T I C L V T V G L N L L V L Y A V R S E T V G N L Y I V S L S V A D L I V G A V V M P M N I L Y L L M G R P L C L F W L S M D Y V A S T A S I F S V F I L C I D R Y R S V Q Q T K T R A S A T I L G A W F L S F L W V I P I L G V T W F K V M T A I I N F Y L P T L L M L W F Y A K I Y K A V R Q H C Q H R E L I N G L H M N R E R K A A K Q L G F I M A A F I L C W I P Y F I F F M V I A F C N E H L H M F T I W L G Y I N S T L N P L I Y P L C N E N F K R F K K T I L H
Helix box plot — Download: PNG | SVG L N L G V T V L C I T S L V V V L P 1 V S L S V A D L I V G V A V M P M N I L Y 2 I F V S F I S A T S A V Y D M S L W F L 3 A S A T I L G A W F L S F L W V I P I 4 Y F W L M L L T P L Y F N I I A T M V K F 5 G F I M A A F I L C W I P Y F I F F M V 6 L P N L T S N I Y G L W I T F M H L H 7

GPCRdb(A)
GPCRdb(A)
H1 receptor
TM3
3x32 3.32x32 D107
3x33 3.33x33 Y108
3x36 3.36x36 S111
3x37 3.37x37 T112
TM5
5x461 5.46x461 N198
TM6
6x51 6.51x51 Y431
6x52 6.52x52 F432
TM7
7x38 7.39x38 I454
7x42 7.43x42 Y458