PDB
7DTY
Resolution
3.0 Å
Released
Aug. 4, 2021
Receptor
GIP
Class
B1
Species
Homo sapiens
Ligand
Gastric inhibitory polypeptide
Function
Agonist
Reference
10.7554/ELIFE.68719

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Ligand Amino Acid Generic Number Segment Interaction Type
Gastric inhibitory polypeptide L35 N-term hydrophobic
Gastric inhibitory polypeptide Y36 N-term polar (hydrogen bond)
Gastric inhibitory polypeptide Y36 N-term Van der Waals
Gastric inhibitory polypeptide W39 N-term aromatic (face-to-edge)
Gastric inhibitory polypeptide W39 N-term Van der Waals
Gastric inhibitory polypeptide D66 N-term Van der Waals
Gastric inhibitory polypeptide M67 N-term Van der Waals
Gastric inhibitory polypeptide M67 N-term hydrophobic
Gastric inhibitory polypeptide Y68 N-term Van der Waals
Gastric inhibitory polypeptide Y68 N-term hydrophobic
Gastric inhibitory polypeptide W90 N-term Van der Waals
Gastric inhibitory polypeptide R101 N-term Van der Waals
Gastric inhibitory polypeptide R113 N-term Van der Waals
Gastric inhibitory polypeptide H115 N-term Van der Waals
Gastric inhibitory polypeptide N124 1.26x26 TM1 polar (hydrogen bond)
Gastric inhibitory polypeptide N124 1.26x26 TM1 Van der Waals
Gastric inhibitory polypeptide R131 1.33x33 TM1 polar (charge-assisted hydrogen bond)
Gastric inhibitory polypeptide L134 1.36x36 TM1 Van der Waals
Gastric inhibitory polypeptide L134 1.36x36 TM1 hydrophobic
Gastric inhibitory polypeptide L137 1.39x39 TM1 Van der Waals
Gastric inhibitory polypeptide L137 1.39x39 TM1 hydrophobic
Gastric inhibitory polypeptide Q138 1.40x40 TM1 Van der Waals
Gastric inhibitory polypeptide Y141 1.43x43 TM1 aromatic (edge-to-face)
Gastric inhibitory polypeptide Y141 1.43x43 TM1 Van der Waals
Gastric inhibitory polypeptide Y145 1.47x47 TM1 polar (hydrogen bond)
Gastric inhibitory polypeptide R183 2.60x60 TM2 polar (charge-assisted hydrogen bond)
Gastric inhibitory polypeptide R190 2.67x67 TM2 polar (charge-assisted hydrogen bond)
Gastric inhibitory polypeptide G198 ECL1 Van der Waals
Gastric inhibitory polypeptide P199 ECL1 polar (hydrogen bond with backbone)
Gastric inhibitory polypeptide P199 ECL1 Van der Waals
Gastric inhibitory polypeptide L201 ECL1 Van der Waals
Gastric inhibitory polypeptide G202 ECL1 Van der Waals
Gastric inhibitory polypeptide Q204 ECL1 Van der Waals
Gastric inhibitory polypeptide Q224 3.37x37 TM3 Van der Waals
Gastric inhibitory polypeptide Q224 3.37x37 TM3 polar (hydrogen bond)
Gastric inhibitory polypeptide V227 3.40x40 TM3 Van der Waals
Gastric inhibitory polypeptide V227 3.40x40 TM3 hydrophobic
Gastric inhibitory polypeptide E288 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
Gastric inhibitory polypeptide E288 45.52x52 ECL2 polar (hydrogen bond with backbone)
Gastric inhibitory polypeptide R289 ECL2 polar (charge-assisted hydrogen bond)
Gastric inhibitory polypeptide N290 ECL2 Van der Waals
Gastric inhibitory polypeptide N290 ECL2 polar (hydrogen bond)
Gastric inhibitory polypeptide W296 5.36x37 TM5 Van der Waals
Gastric inhibitory polypeptide W296 5.36x37 TM5 hydrophobic
Gastric inhibitory polypeptide R370 7.35x34 TM7 polar (charge-assisted hydrogen bond)
Gastric inhibitory polypeptide L374 7.39x38 TM7 Van der Waals
Gastric inhibitory polypeptide L374 7.39x38 TM7 hydrophobic
Gastric inhibitory polypeptide E377 7.42x41 TM7 Van der Waals
Gastric inhibitory polypeptide I378 7.43x42 TM7 hydrophobic
Gastric inhibitory polypeptide I378 7.43x42 TM7 Van der Waals
Gastric inhibitory polypeptide S381 7.46x45 TM7 polar (hydrogen bond)

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ICL1 R R L H ICL1ECL1 P R P G P Y L G D Q A L A L W N ECL1ICL2 V G G S E E G ICL2ECL2 N T Q C W E R N E V ECL2ICL3 Q M ICL3ECL3 T E E Q A R ECL3N-term M T T S P I L Q L L L R L S L C G L L L Q R A E T G S K G Q T A G E L Y Q R W E R Y R R E C Q E T L A A A E P P S G L A C N G S F D M Y V C W D Y A A P N A T A R A S C P W Y L P W H H H V A A G F V L R Q C G S D G Q W G L W R D H T Q C E N P E K N-termC-term Q L P E R A F R A L P S G S G P G E V P T S R G L S S G T L P G P G N E A S R E L E S Y C C-term N E A F L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F C T R N Y I H I N L F T S F M L R A A A I L S R D R L L Q A L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E K A I W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T R R C R D Y R L R L A R S T L T L V P L L G V H E V V F A P V G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E I R R C R L G E E V Q S E G W H H R R S L Q R
Helix box plot — Download: PNG | SVG L L T A L S L S Y G V T Y M V Q L R E L 1 I N L F T S F M L R A A A I L S R D R L 2 V L L W T Y N A G V C Y Q T V I Q A T R 3 H F R Y Y L L G L W G A P A L F V I P W V 4 F I L F N I L I T M L I P T R I I W W I A 5 L T L V P L L G V H E V V F A P V 6 V S V L F G Q F S S L F I E F G L K A 7

GPCRdb(A)
GPCRdb(B)
GIP receptor
TM1
1x22 1.26x26 N124
1x29 1.33x33 R131
1x32 1.36x36 L134
1x35 1.39x39 L137
1x36 1.40x40 Q138
1x39 1.43x43 Y141
1x43 1.47x47 Y145
TM2
2x53 2.60x60 R183
2x60 2.67x67 R190
TM3
3x33 3.37x37 Q224
3x36 3.40x40 V227
ECL2
45x52 45.52x52 E288
TM5
5x41 5.36x37 W296
TM7
7x30 7.35x34 R370
7x34 7.39x38 L374
7x37 7.42x41 E377
7x38 7.43x42 I378
7x41 7.46x45 S381