PDB
7E9G
Resolution
3.5 Å
Released
June 23, 2021
Receptor
mGlu2
Class
C
Species
Homo sapiens
Ligands
Function
eglumegad
Agonist
DN13
PAM
JNJ-40411813
PAM
Reference
10.1038/S41586-021-03495-2
eglumegad DN13 JNJ-40411813

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Ligand Amino Acid Generic Number Segment Interaction Type
eglumegad R57 N-term polar (charge-charge)
eglumegad R61 N-term polar (hydrogen bond)
eglumegad R61 N-term polar (charge-charge)
eglumegad S143 N-term Van der Waals
eglumegad Y144 N-term hydrophobic
eglumegad S145 N-term polar (hydrogen bond)
eglumegad A166 N-term Van der Waals
eglumegad S167 N-term Van der Waals
eglumegad T168 N-term polar (hydrogen bond)
eglumegad T168 N-term polar (hydrogen bond with backbone)
DN13 S173 N-term Van der Waals
DN13 P187 N-term Van der Waals
DN13 F189 N-term aromatic (edge-to-face)
DN13 F189 N-term hydrophobic
DN13 F190 N-term hydrophobic
DN13 K193 N-term Van der Waals
eglumegad Y216 N-term hydrophobic
eglumegad Y216 N-term aromatic (pi-cation)
eglumegad Y216 N-term polar (hydrogen bond)
DN13 E222 N-term hydrophobic
DN13 A223 N-term hydrophobic
DN13 L226 N-term hydrophobic
DN13 E227 N-term polar (hydrogen bond)
eglumegad R271 N-term hydrophobic
eglumegad D295 N-term polar (charge-charge)
eglumegad G296 N-term Van der Waals
eglumegad K377 N-term polar (hydrogen bond)
eglumegad K377 N-term polar (charge-charge)
DN13 R445 N-term polar (hydrogen bond with backbone)
DN13 F446 N-term hydrophobic
DN13 D448 N-term polar (hydrogen bond)
DN13 D448 N-term polar (charge-charge)
JNJ-40411813 L639 3.36x36 TM3 hydrophobic
JNJ-40411813 F643 3.40x40 TM3 hydrophobic
JNJ-40411813 Y647 3.44x44 TM3 polar (hydrogen bond)
JNJ-40411813 M728 5.40x40 TM5 hydrophobic
JNJ-40411813 L732 5.44x44 TM5 hydrophobic
JNJ-40411813 N735 5.47x47 TM5 Van der Waals
JNJ-40411813 I739 5.51x51 TM5 Van der Waals
JNJ-40411813 W773 6.50x50 TM6 hydrophobic
JNJ-40411813 L774 6.51x51 TM6 Van der Waals
JNJ-40411813 L777 6.54x54 TM6 hydrophobic
JNJ-40411813 F780 6.57x57 TM6 aromatic (edge-to-face)
JNJ-40411813 F780 6.57x57 TM6 hydrophobic
JNJ-40411813 S784 6.61x61 TM6 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 T N A P V V K A S ICL1ECL1 K P ECL1ICL2 A R E G A Q R P R F I ICL2ECL2 A P G T G K E T A P E R R E V V T L R C N H R ECL2ICL3 P E N ICL3ECL3 S ECL3N-term M G S L L A L L A L L L L W G A V A E G P A K K V L T L E G D L V L G G L F P V H Q K G G P A E D C G P V N E H R G I Q R L E A M L F A L D R I N R D P H L L P G V R L G A H I L D S C S K D T H A L E Q A L D F V R A S L S R G A D G S R H I C P D G S Y A T H G D A P T A I T G V I G G S Y S D V S I Q V A N L L R L F Q I P Q I S Y A S T S A K L S D K S R Y D Y F A R T V P P D F F Q A K A M A E I L R F F N W T Y V S T V A S E G D Y G E T G I E A F E L E A R A R N I C V A T S E K V G R A M S R A A F E G V V R A L L Q K P S A R V A V L F T R S E D A R E L L A A S Q R L N A S F T W V A S D G W G A L E S V V A G S E G A A E G A I T I E L A S Y P I S D F A S Y F Q S L D P W N N S R N P W F R E F W E Q R F R C S F R Q R D C A A H S L R A V P F E Q E S K I M F V V N A V Y A M A H A L H N M H R A L C P N T T R L C D A M R P V N G R R L Y K D F V L N V K F D A P F R P A D T H N E V R F D R F G D G I G R Y N I F T Y L R A G S G R Y R Y Q K V G Y W A E G L T L D T S L I P W A S P S A G P L P A S R C S E P C L Q N E V K S V Q P G E V C C W L C I P C Q P Y E Y R L D E F T C A D C G L G Y W P N A S L T G C F E L P Q E Y I R W N-termC-term S R F G S A A A R A S S S L G Q G S G S Q F V P T V C N G R E V V D S T T S S L C-term G D A W A V G P V T I A C L G A L A T L F V L G V F V R H G R E L C Y I L L G G V F L C Y C M T F I F I A S T A V C T L R R L G L G T A F S V C Y S A L L T K T N R I A R I F G G S P A S Q V A I C L A L I S G Q L L I V V A W L V V E D A S M L G S L A Y N V L L I A L C T L Y A F K T R K C F N E A K F I G F T M Y T T C I I W L A F L P I F Y V T S D Y R V Q T T T M C V S V S L S G S V V L G C L F A P K L H I I L F Q P Q K H R A N V V S P T
Helix box plot — Download: PNG | SVG L T A L A G L C A I T V P G V A W A D G 1 Y I L L G G V F L C Y C M T F I F I A 2 T L L A S Y C V S F A T G L G L R R L T 3 Q V A I C L A L I S G Q L L I V V A W L 4 A Y L T C L A I L L V N Y A L S G L M S 5 G F T M Y T T C I I W L A F L P I F Y V 6 G L V V S G S L S V S V C M T T T Q V R 7

GPCRdb(A)
GPCRdb(C)
mGlu2 receptor
TM3
3x32 3.36x36 L639
3x36 3.40x40 F643
3x40 3.44x44 Y647
TM5
5x40 5.40x40 M728
5x44 5.44x44 L732
5x47 5.47x47 N735
5x51 5.51x51 I739
TM6
6x48 6.50x50 W773
6x49 6.51x51 L774
6x52 6.54x54 L777
6x55 6.57x57 F780
6x59 6.61x61 S784