PDB
7E9H
Resolution
4.0 Å
Released
June 23, 2021
Receptor
mGlu4
Class
C
Species
Homo sapiens
Ligand
L-serine-O-phosphate
Function
Agonist
Reference
10.1038/S41586-021-03495-2

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Ligand Amino Acid Generic Number Segment Interaction Type
L-serine-O-phosphate K74 N-term polar (charge-assisted hydrogen bond)
L-serine-O-phosphate R78 N-term polar (charge-assisted hydrogen bond)
L-serine-O-phosphate S157 N-term Van der Waals
L-serine-O-phosphate G158 N-term Van der Waals
L-serine-O-phosphate S159 N-term Van der Waals
L-serine-O-phosphate S159 N-term polar (hydrogen bond with backbone)
L-serine-O-phosphate S159 N-term polar (hydrogen bond)
L-serine-O-phosphate A180 N-term Van der Waals
L-serine-O-phosphate A180 N-term polar (hydrogen bond with backbone)
L-serine-O-phosphate S181 N-term Van der Waals
L-serine-O-phosphate T182 N-term polar (hydrogen bond with backbone)
L-serine-O-phosphate T182 N-term Van der Waals
L-serine-O-phosphate Y230 N-term hydrophobic
L-serine-O-phosphate Y230 N-term Van der Waals
L-serine-O-phosphate S313 N-term polar (hydrogen bond with backbone)
L-serine-O-phosphate S313 N-term Van der Waals
L-serine-O-phosphate K405 N-term polar (charge-assisted hydrogen bond)

NGL is a WebGL based 3D viewer powered by MMTF.

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Snake plot — Download: PNG | SVG
ICL1 T N D P I V K A S ICL1ECL1 A E P ECL1ICL2 V S A P R F I ICL2ECL2 P S H S V V D F Q D Q R T L D P R F A R G V L K C D I ECL2ICL3 R G V P E T F N E ICL3ECL3 A D ECL3N-term M P G K R G L G W W W A R L P L C L L L S L Y G P W M P S S L G K P K G H P H M N S I R I D G D I T L G G L F P V H G R G S E G K P C G E L K K E K G I H R L E A M L F A L D R I N N D P D L L P N I T L G A R I L D T C S R D T H A L E Q S L T F V Q A L I E K D G T E V R C G S G G P P I I T K P E R V V G V I G A S G S S V S I M V A N I L R L F K I P Q I S Y A S T A P D L S D N S R Y D F F S R V V P S D T Y Q A Q A M V D I V R A L K W N Y V S T V A S E G S Y G E S G V E A F I Q K S R E D G G V C I A Q S V K I P R E P K A G E F D K I I R R L L E T S N A R A V I I F A N E D D I R R V L E A A R R A N Q T G H F F W M G S D S W G S K I A P V L H L E E V A E G A V T I L P K R M S V R G F D R Y F S S R T L D N N R R N I W F A E F W E D N F H C K L S R H A L K K G S H V K K C T N R E R I G Q D S A Y E Q E G K V Q F V I D A V Y A M G H A L H A M H R D L C P G R V G L C P R M D P V D G T Q L L K Y I R N V N F S G I A G N P V T F N E N G D A P G R Y D I Y Q Y Q L R N D S A E Y K V I G S W T D H L H L R I E R M H W P G S G Q Q L P R S I C S L P C Q P G E R K K T V K G M P C C W H C E P C T G Y Q Y Q V D R Y T C K T C P Y D M R P T E N R T G C R P I P I I K L E W G S N-termC-term K A V V T A A T M S N K F T Q K G N F R P N G E A K S E L C E N L E A P A L A T K Q T Y V T Y T N H A I C-term P W A V L P L F L A V V G I A A T L F V V I T F V R Y G R E L S Y V L L A G I F L C Y A T T F L M I D L G T C S L R R I F L G L G M S I S Y A A L L T K T N R I Y R I F E Q G K R S S P A S Q L A I T F S L I S L Q L L G I C V W F V V D S D L S L I C L L G Y S M L L M V T C T V Y A I K T A K P I G F T M Y T T C I V W L A F I P I F F G T S Q S K L Y I Q T T T L T V S V S L S A S V S L G M L Y M P K V Y I I L F H P E Q R K R N V P K S L
Helix box plot — Download: PNG | SVG L T A A I G V V A L F L P L V A W P 1 Y V L L A G I F L C Y A T T F L M I 2 T L L A A Y S I S M G L G L F I R R L S 3 Q L A I T F S L I S L Q L L G I C V W F 4 A Y V T C T V M L L M S Y G L L C I L S 5 G F T M Y T T C I V W L A F I P I F F G 6 G L S V S A S L S V S V T L T T T Q I Y 7

GPCRdb(A)
GPCRdb(C)
mGlu4 receptor