PDB
7EJ8
Resolution
3.0 Å
Released
April 13, 2022
Receptor
α2A
Class
A
Species
Homo sapiens
Ligand
Function
brimonidine (UK14304)
Agonist
Reference
10.1126/SCIADV.ABJ5347

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Ligand Amino Acid Generic Number Segment Interaction Type
brimonidine (UK14304) D128 3.32x32 TM3 polar (hydrogen bond)
brimonidine (UK14304) D128 3.32x32 TM3 polar (charge-charge)
brimonidine (UK14304) V129 3.33x33 TM3 hydrophobic
brimonidine (UK14304) C132 3.36x36 TM3 hydrophobic
brimonidine (UK14304) T133 3.37x37 TM3 Van der Waals
brimonidine (UK14304) I205 45.52x52 ECL2 Van der Waals
brimonidine (UK14304) S215 5.42x43 TM5 Van der Waals
brimonidine (UK14304) C216 5.43x44 TM5 Van der Waals
brimonidine (UK14304) S219 5.46x461 TM5 Van der Waals
brimonidine (UK14304) W402 6.48x48 TM6 Van der Waals
brimonidine (UK14304) F405 6.51x51 TM6 aromatic (edge-to-face)
brimonidine (UK14304) F406 6.52x52 TM6 aromatic (edge-to-face)
brimonidine (UK14304) Y409 6.55x55 TM6 hydrophobic
brimonidine (UK14304) Y409 6.55x55 TM6 aromatic (edge-to-face)
brimonidine (UK14304) F427 7.39x38 TM7 Van der Waals
brimonidine (UK14304) Y431 7.43x42 TM7 polar (hydrogen bond)

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ICL1 R A L K ICL1ECL1 Y W Y F ECL1ICL2 A I E Y N L K R ICL2ECL2 S I E K K G G G G G P Q P A E P R C E I N D ECL2ICL3 R G P D A V A A P P G G T E R R P N G L G P E R S A G P G G A E A E P L P T Q L N G A P G E P A P A G P R D T D A L D L E E S S S S D H A E R P P G P R R P E R G P R G K G K A R A S Q V K P G D S L P R R G P G A T G I G T P A A G P G E E R V G A A K A S R W ICL3ECL3 C S V ECL3N-term M F R Q E Q P L A E G S F A P M G S L Q P D A G N A S W N G T E A P G G G A R A T P Y S L N-termC-term G D R K R I V C-term Q V T L T L V C L A G L L M L L T V F G N V L V I I A V F T S A P Q N L F L V S L A S A D I L V A T L V I P F S L A N E V M G G K A W C E I Y L A L D V L F C T S S I V H L C A I S L D R Y W S I T Q T P R R I K A I I I T V W V I S A V I S F P P L I Q K W Y V I S S C I G S F F A P C L I M I L V Y V R I Y Q I A K R R T R V P P S R R G R Q N R E K R F T F V L A V V I G V F V V C W F P F F F T Y T L T A V G P R T L F K F F F W F G Y C N S S L N P V I Y T I F N H D F K K F R R A I L C R
Helix box plot — Download: PNG | SVG V N G F V T L L M L L G A L C V L T L T 1 V S L A S A D I L V A L T V I P F S L A N 2 A C L H V I S S T C F L V D L A L Y I E 3 I K A I I I T V W V I S A V I S F P P L 4 Y V L I M I L C P A F F S G I C S S I V Y 5 A V V I G V F V V C W F P F F F T Y T L 6 V P N L S S N C Y G F W F F F K F L T 7

GPCRdb(A)
GPCRdb(A)
α2A-adrenoceptor
TM3
3x32 3.32x32 D128
3x33 3.33x33 V129
3x36 3.36x36 C132
3x37 3.37x37 T133
ECL2
45x52 45.52x52 I205
TM5
5x43 5.42x43 S215
5x44 5.43x44 C216
5x461 5.46x461 S219
TM6
6x48 6.48x48 W402
6x51 6.51x51 F405
6x52 6.52x52 F406
6x55 6.55x55 Y409
TM7
7x38 7.39x38 F427
7x42 7.43x42 Y431