PDB
7EJA
Resolution
3.6 Å
Released
April 13, 2022
Receptor
α2A
Class
A
Species
Homo sapiens
Ligand
Function
dexmedetomidine
Agonist
Reference
10.1126/SCIADV.ABJ5347

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Ligand Amino Acid Generic Number Segment Interaction Type
dexmedetomidine D128 3.32x32 TM3 Van der Waals
dexmedetomidine V129 3.33x33 TM3 hydrophobic
dexmedetomidine C132 3.36x36 TM3 hydrophobic
dexmedetomidine S215 5.42x43 TM5 Van der Waals
dexmedetomidine S219 5.46x461 TM5 Van der Waals
dexmedetomidine W402 6.48x48 TM6 Van der Waals
dexmedetomidine F405 6.51x51 TM6 hydrophobic
dexmedetomidine F405 6.51x51 TM6 aromatic (edge-to-face)
dexmedetomidine Y409 6.55x55 TM6 hydrophobic
dexmedetomidine F427 7.39x38 TM7 hydrophobic
dexmedetomidine F427 7.39x38 TM7 aromatic (edge-to-face)
dexmedetomidine Y431 7.43x42 TM7 polar (hydrogen bond)

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ICL1 R A L K ICL1ECL1 Y W Y F ECL1ICL2 A I E Y N L K R ICL2ECL2 S I E K K G G G G G P Q P A E P R C E I N D ECL2ICL3 R G P D A V A A P P G G T E R R P N G L G P E R S A G P G G A E A E P L P T Q L N G A P G E P A P A G P R D T D A L D L E E S S S S D H A E R P P G P R R P E R G P R G K G K A R A S Q V K P G D S L P R R G P G A T G I G T P A A G P G E E R V G A A K A S R W ICL3ECL3 C S V ECL3N-term M F R Q E Q P L A E G S F A P M G S L Q P D A G N A S W N G T E A P G G G A R A T P Y S L N-termC-term G D R K R I V C-term Q V T L T L V C L A G L L M L L T V F G N V L V I I A V F T S A P Q N L F L V S L A S A D I L V A T L V I P F S L A N E V M G G K A W C E I Y L A L D V L F C T S S I V H L C A I S L D R Y W S I T Q T P R R I K A I I I T V W V I S A V I S F P P L I Q K W Y V I S S C I G S F F A P C L I M I L V Y V R I Y Q I A K R R T R V P P S R R G R Q N R E K R F T F V L A V V I G V F V V C W F P F F F T Y T L T A V G P R T L F K F F F W F G Y C N S S L N P V I Y T I F N H D F K K F R R A I L C R
Helix box plot — Download: PNG | SVG V N G F V T L L M L L G A L C V L T L T 1 V S L A S A D I L V A L T V I P F S L A N 2 A C L H V I S S T C F L V D L A L Y I E 3 I K A I I I T V W V I S A V I S F P P L 4 Y V L I M I L C P A F F S G I C S S I V Y 5 A V V I G V F V V C W F P F F F T Y T L 6 V P N L S S N C Y G F W F F F K F L T 7

GPCRdb(A)
GPCRdb(A)
α2A-adrenoceptor
TM3
3x32 3.32x32 D128
3x33 3.33x33 V129
3x36 3.36x36 C132
TM5
5x43 5.42x43 S215
5x461 5.46x461 S219
TM6
6x48 6.48x48 W402
6x51 6.51x51 F405
6x55 6.55x55 Y409
TM7
7x38 7.39x38 F427
7x42 7.43x42 Y431