PDB
7EPB
Resolution
3.1 Å
Released
June 23, 2021
Receptor
mGlu2
Class
C
Species
Homo sapiens
Ligands
Nanobody DN13
eglumegad
Function
PAM
Agonist
Reference
10.1038/S41586-021-03641-W
Nanobody DN13 eglumegad

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Nanobody DN13 P46 N-term hydrophobic
Nanobody DN13 A47 N-term hydrophobic
Nanobody DN13 E48 N-term polar (charge-assisted hydrogen bond)
Nanobody DN13 G51 N-term Van der Waals
Nanobody DN13 P52 N-term Van der Waals
eglumegad R57 N-term polar (charge-assisted hydrogen bond)
eglumegad R61 N-term polar (charge-assisted hydrogen bond)
eglumegad S143 N-term polar (hydrogen bond with backbone)
eglumegad S143 N-term Van der Waals
eglumegad Y144 N-term hydrophobic
eglumegad Y144 N-term Van der Waals
eglumegad S145 N-term polar (hydrogen bond)
eglumegad S145 N-term polar (hydrogen bond with backbone)
eglumegad S145 N-term polar (hydrogen bond)
eglumegad A166 N-term Van der Waals
eglumegad A166 N-term polar (hydrogen bond with backbone)
eglumegad S167 N-term Van der Waals
eglumegad T168 N-term Van der Waals
eglumegad T168 N-term polar (hydrogen bond with backbone)
eglumegad Y216 N-term Van der Waals
eglumegad Y216 N-term hydrophobic
Nanobody DN13 E239 N-term polar (charge-assisted hydrogen bond)
Nanobody DN13 K240 N-term Van der Waals
Nanobody DN13 K240 N-term polar (hydrogen bond with backbone)
Nanobody DN13 V241 N-term Van der Waals
Nanobody DN13 V241 N-term polar (hydrogen bond with backbone)
Nanobody DN13 G242 N-term Van der Waals
Nanobody DN13 A244 N-term Van der Waals
Nanobody DN13 A244 N-term polar (hydrogen bond with backbone)
Nanobody DN13 M245 N-term polar (hydrogen bond with backbone)
Nanobody DN13 M245 N-term Van der Waals
Nanobody DN13 S246 N-term polar (hydrogen bond)
Nanobody DN13 R247 N-term Van der Waals
Nanobody DN13 R247 N-term polar (hydrogen bond with backbone)
Nanobody DN13 A248 N-term hydrophobic
Nanobody DN13 A248 N-term Van der Waals
Nanobody DN13 A249 N-term hydrophobic
Nanobody DN13 A249 N-term Van der Waals
Nanobody DN13 V253 N-term Van der Waals
Nanobody DN13 V253 N-term hydrophobic
eglumegad D295 N-term polar (charge-assisted hydrogen bond)
eglumegad K377 N-term polar (charge-assisted hydrogen bond)

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 T N A P V V K A S ICL1ECL1 K P ECL1ICL2 A R E G A Q R P R F I ICL2ECL2 A P G T G K E T A P E R R E V V T L R C N H R ECL2ICL3 P E N ICL3ECL3 S ECL3N-term M G S L L A L L A L L L L W G A V A E G P A K K V L T L E G D L V L G G L F P V H Q K G G P A E D C G P V N E H R G I Q R L E A M L F A L D R I N R D P H L L P G V R L G A H I L D S C S K D T H A L E Q A L D F V R A S L S R G A D G S R H I C P D G S Y A T H G D A P T A I T G V I G G S Y S D V S I Q V A N L L R L F Q I P Q I S Y A S T S A K L S D K S R Y D Y F A R T V P P D F F Q A K A M A E I L R F F N W T Y V S T V A S E G D Y G E T G I E A F E L E A R A R N I C V A T S E K V G R A M S R A A F E G V V R A L L Q K P S A R V A V L F T R S E D A R E L L A A S Q R L N A S F T W V A S D G W G A L E S V V A G S E G A A E G A I T I E L A S Y P I S D F A S Y F Q S L D P W N N S R N P W F R E F W E Q R F R C S F R Q R D C A A H S L R A V P F E Q E S K I M F V V N A V Y A M A H A L H N M H R A L C P N T T R L C D A M R P V N G R R L Y K D F V L N V K F D A P F R P A D T H N E V R F D R F G D G I G R Y N I F T Y L R A G S G R Y R Y Q K V G Y W A E G L T L D T S L I P W A S P S A G P L P A S R C S E P C L Q N E V K S V Q P G E V C C W L C I P C Q P Y E Y R L D E F T C A D C G L G Y W P N A S L T G C F E L P Q E Y I R W N-termC-term S R F G S A A A R A S S S L G Q G S G S Q F V P T V C N G R E V V D S T T S S L C-term G D A W A V G P V T I A C L G A L A T L F V L G V F V R H G R E L C Y I L L G G V F L C Y C M T F I F I A S T A V C T L R R L G L G T A F S V C Y S A L L T K T N R I A R I F G G S P A S Q V A I C L A L I S G Q L L I V V A W L V V E D A S M L G S L A Y N V L L I A L C T L Y A F K T R K C F N E A K F I G F T M Y T T C I I W L A F L P I F Y V T S D Y R V Q T T T M C V S V S L S G S V V L G C L F A P K L H I I L F Q P Q K H R A N V V S P T
Helix box plot — Download: PNG | SVG L T A L A G L C A I T V P G V A W A D G 1 Y I L L G G V F L C Y C M T F I F I A 2 T L L A S Y C V S F A T G L G L R R L T 3 Q V A I C L A L I S G Q L L I V V A W L 4 A Y L T C L A I L L V N Y A L S G L M S 5 G F T M Y T T C I I W L A F L P I F Y V 6 G L V V S G S L S V S V C M T T T Q V R 7

GPCRdb(A)
GPCRdb(C)
mGlu2 receptor