Structure information

FPR1

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7EUO

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-32822-Y

PUBLICATION DATE

May 25, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Peptide Agonist fMLF D106 3.33x33 TM3 polar (charge-assisted hydrogen bond)
Peptide Agonist fMLF L109 3.36x36 TM3 hydrophobic
Peptide Agonist fMLF L109 3.36x36 TM3 Van der Waals
Peptide Agonist fMLF F110 3.37x37 TM3 Van der Waals
Peptide Agonist fMLF F110 3.37x37 TM3 hydrophobic
Peptide Agonist fMLF L198 5.35x36 TM5 hydrophobic
Peptide Agonist fMLF R201 5.38x39 TM5 polar (charge-assisted hydrogen bond)
Peptide Agonist fMLF R205 5.42x43 TM5 polar (charge-assisted hydrogen bond)
Peptide Agonist fMLF W254 6.48x48 TM6 hydrophobic
Peptide Agonist fMLF Y257 6.51x51 TM6 polar (hydrogen bond)
Peptide Agonist fMLF Y257 6.51x51 TM6 polar (hydrogen bond)
Peptide Agonist fMLF V283 7.35x34 TM7 Van der Waals
Peptide Agonist fMLF V283 7.35x34 TM7 hydrophobic

Ligands

Peptide Agonist fMLF

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Residue Diagrams

G N G L V G L V F T V A F V L Y T I I D 1 L N L A V A D F C F T S T L P F F M V R 2 L A I L F V S G F L N I D V I T F V F K 3 A K K V I I G P W V M A L L L T L P V 4 Y S V A V I S M P A S F G I I F R I I G R 5 S F V A A A F F L C W S P Y Q V V A L I 6 M P N L C S N F F A L A S T V D V A I 7
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ICL1 T H ICL1ECL1 G H W P F ECL1ICL2 P V W T Q N H R ICL2ECL2 T T V P G K T G T V A C T F N F S P W T N ECL2ICL3 L I K S ICL3ECL3 I R E L L Q G M ECL3N-term M E T N S S L P T N I S G G T P A V N-termC-term P A S L E R A L T E D S T Q T S D T A T N S T L P S A E V E L Q A K C-term S A G Y L F L D I I T Y L V F A V T F V L G V L G N G L V I W V A G F R M T V T T I S Y L N L A V A D F C F T S T L P F F M V R K A M G G W F L C K F V F T I V D I N L F G S V F L I A L I A L D R C V C V L H T V S L A K K V I I G P W V M A L L L T L P V I I R V D P K E R I N V A V A M L T V R G I I R F I I G F S A P M S I V A V S Y G L I A T K I H K Q G S R P L R V L S F V A A A F F L C W S P Y Q V V A L I A T V R Y K E I G I A V D V T S A L A F F N S C L N P M L Y V F M G Q D L I H F R E R A L
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Residue Table


GPCRdb(A)
GPCRdb(A)
FPR1
TM3
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
TM5
5x36 5.35x36 L198
5x39 5.38x39 R201
5x43 5.42x43 R205
TM6
6x48 6.48x48 W254
6x51 6.51x51 Y257
TM7
7x34 7.35x34 V283