Structure information

CCR5

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7F1R

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

July 14, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CCL5 V178 2.57x57 TM2 hydrophobic
CCL5 W181 2.60x60 TM2 aromatic (face-to-face)
CCL5 Q265 ECL2 polar (hydrogen bond)
CCL5 C267 ECL2 polar (hydrogen bond)
CCL5 T272 ECL2 polar (hydrogen bond)
CCL5 T272 ECL2 Van der Waals
CCL5 C273 45.50x50 ECL2 polar (hydrogen bond with backbone)
CCL5 C273 45.50x50 ECL2 Van der Waals
CCL5 S274 45.51x51 ECL2 polar (hydrogen bond)
CCL5 S274 45.51x51 ECL2 Van der Waals
CCL5 S275 45.52x52 ECL2 polar (hydrogen bond with backbone)
CCL5 S275 45.52x52 ECL2 Van der Waals
CCL5 H276 ECL2 Van der Waals
CCL5 Y282 5.31x32 TM5 polar (hydrogen bond)
CCL5 Y282 5.31x32 TM5 Van der Waals
CCL5 K286 5.35x36 TM5 polar (charge-assisted hydrogen bond)
CCL5 Y346 6.51x51 TM6 polar (hydrogen bond)
CCL5 N353 6.58x58 TM6 Van der Waals
CCL5 Q356 6.61x61 TM6 Van der Waals
CCL5 G360 ECL3 Van der Waals
CCL5 N362 ECL3 Van der Waals
CCL5 N363 ECL3 Van der Waals
CCL5 E378 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

CCL5

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Residue Diagrams

M N G V F G F I F V L S Y L P P L L R A 1 L N L A I S D L F F L L T V P F W A H Y 2 L I I F F I G S F F G I F Y L G T L L Q 3 G V V T S V I T W V V A V F A S L P G 4 Y C I V M V L L P L V L G L I V I K L T Q 5 F T I M I V Y F L F W A P Y N I V L L L 6 I P N I C C H T M G L T E T V Q M A Q 7
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ICL1 K R L K ICL1ECL1 Q W D F ECL1ICL2 A V F A L K A R ICL2ECL2 R S Q K E G L H Y T C S S H F P Y S ECL2ICL3 R ICL3ECL3 L N ECL3N-term M D Y Q V S S P I Y D I N Y Y T S E P C Q N-termC-term K H I A K R F C K C C S I F Q Q E A P E R A S S V Y T R S T G E Q E I S V G L C-term K I N V K Q I A A R L L P P L Y S L V F I F G F V G N M L V I L I L I N C S M T D I Y L L N L A I S D L F F L L T V P F W A H Y A A A G N T M C Q L L T G L Y F I G F F S G I F F I I L L T I D R Y L A V V H T V T F G V V T S V I T W V V A V F A S L P G I I F T Q Y Q F W K N F Q T L K I V I L G L V L P L L V M V I C Y S G I L K T L L R C N E K K R H R A V R L I F T I M I V Y F L F W A P Y N I V L L L N T F Q E F F G N C S S S N R L D Q A M Q V T E T L G M T H C C I N P I I Y A F V G E K L L V F R N Y F F Q
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCR5
TM2
2x57 2.57x57 V83
2x60 2.60x60 W86
ECL2
45x50 45.50x50 C178
45x51 45.51x51 S179
45x52 45.52x52 S180
TM5
5x32 5.31x32 Y187
5x36 5.35x36 K191
TM6
6x51 6.51x51 Y251
6x58 6.58x58 N258
6x61 6.61x61 Q261
TM7
7x38 7.39x38 E283