Structure information

D1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7F24

SPECIES

Homo sapiens

RESOLUTION

4.160

PREFERRED CHAIN

F

REFERENCE

10.1126/SCIADV.ABO4158

PUBLICATION DATE

June 15, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
dopamine D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
dopamine I104 3.33x33 TM3 Van der Waals
dopamine I104 3.33x33 TM3 hydrophobic
dopamine S107 3.36x36 TM3 Van der Waals
dopamine S198 5.42x43 TM5 polar (hydrogen bond)
dopamine S198 5.42x43 TM5 polar (hydrogen bond with backbone)
dopamine S199 5.43x44 TM5 polar (hydrogen bond with backbone)
dopamine S199 5.43x44 TM5 Van der Waals
dopamine F288 6.51x51 TM6 Van der Waals
dopamine F288 6.51x51 TM6 hydrophobic
dopamine F289 6.52x52 TM6 hydrophobic
dopamine F289 6.52x52 TM6 Van der Waals
dopamine N292 6.55x55 TM6 polar (hydrogen bond)
dopamine N292 6.55x55 TM6 Van der Waals
dopamine W321 7.43x42 TM7 Van der Waals

Ligands

dopamine

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Residue Diagrams

T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7
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ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
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Residue Table


GPCRdb(A)
GPCRdb(A)
D1 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
TM5
5x43 5.42x43 S198
5x44 5.43x44 S199
TM6
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 N292
TM7
7x42 7.43x42 W321