PDB
7F55
Resolution
3.1 Å
Released
Nov. 3, 2021
Receptor
MC4
Class
A
Species
Homo sapiens
Ligands
Function
bremelanotide
Agonist
Calcium
PAM
Reference
10.1038/S41422-021-00552-3
bremelanotide Calcium

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Ligand Amino Acid Generic Number Segment Interaction Type
bremelanotide F51 1.39x39 TM1 Van der Waals
bremelanotide E100 2.60x60 TM2 polar (charge-charge)
Calcium E100 2.60x60 TM2 metal coordination
bremelanotide I104 2.64x64 TM2 Van der Waals
bremelanotide D122 3.25x25 TM3 polar (charge-charge)
bremelanotide D122 3.25x25 TM3 polar (hydrogen bond)
Calcium D122 3.25x25 TM3 metal coordination
Calcium D126 3.29x29 TM3 metal coordination
bremelanotide D126 3.29x29 TM3 polar (charge-charge)
bremelanotide I129 3.32x32 TM3 hydrophobic
bremelanotide C130 3.33x33 TM3 Van der Waals
bremelanotide L133 3.36x36 TM3 hydrophobic
bremelanotide F184 4.60x60 TM4 Van der Waals
bremelanotide I185 4.61x61 TM4 hydrophobic
bremelanotide S188 4.64x64 TM4 polar (hydrogen bond with backbone)
bremelanotide D189 ECL2 polar (charge-charge)
bremelanotide V193 5.39x39 TM5 hydrophobic
bremelanotide I194 5.40x40 TM5 Van der Waals
bremelanotide F261 6.51x51 TM6 hydrophobic
bremelanotide H264 6.54x54 TM6 polar (hydrogen bond)
bremelanotide L265 6.55x55 TM6 hydrophobic
bremelanotide Y268 6.58x58 TM6 aromatic (edge-to-face)
bremelanotide Y268 6.58x58 TM6 hydrophobic
bremelanotide F284 7.35x34 TM7 hydrophobic
bremelanotide N285 7.36x35 TM7 Van der Waals
bremelanotide L288 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K N L H ICL1ECL1 N S T D T D A ECL1ICL2 A L Q Y H N I M ICL2ECL2 D ECL2ICL3 P G T G A I R ICL3ECL3 P Q N P Y C V C F M S ECL3N-term M V N S T H R G M H T S L H L W N R S S Y R L H S N A S E S L G K G Y S D G G C Y E Q L F V N-termC-term P L G G L C D L S S R Y C-term S P E V F V T L G V I S L L E N I L V I V A I A K N S P M Y F F I C S L A V A D M L V S V S N G S E T I V I T L L Q S F T V N I D N V I D S V I C S S L L A S I C S L L S I A V D R Y F T I F Y T V K R V G I I I S C I W A A C T V S G I L F I I Y S S S A V I I C L I T M F F T M L A L M A S L Y V H M F L M A R L H I K R I A V L Q G A N M K G A I T L T I L I G V F V V C W A P F F L H L I F Y I S C H F N L Y L I L I M C N S I I D P L I Y A L R S Q E F K E Y L R K T I I C C
Helix box plot — Download: PNG | SVG I N E L L S I V G L T V F V E P S 1 C S L A V A D M L V S V S N G S E T I V 2 S L L S C I S A L L S S C I V S D I V N 3 V G I I I S C I W A A C T V S G I L F I 4 Y L S A M L A L M T F F M T I L C I I V 5 T I L I G V F V V C W A P F F L H L I F 6 L P D I I S N C M I L I L Y L N F H 7

GPCRdb(A)
GPCRdb(A)
MC4 receptor
TM1
1x39 1.39x39 F51
TM2
2x60 2.60x60 E100
2x64 2.64x64 I104
TM3
3x25 3.25x25 D122
3x29 3.29x29 D126
3x32 3.32x32 I129
3x33 3.33x33 C130
3x36 3.36x36 L133
TM4
4x60 4.60x60 F184
4x61 4.61x61 I185
4x64 4.64x64 S188
TM5
5x39 5.39x39 V193
5x40 5.40x40 I194
TM6
6x51 6.51x51 F261
6x54 6.54x54 H264
6x55 6.55x55 L265
6x58 6.58x58 Y268
TM7
7x34 7.35x34 F284
7x35 7.36x35 N285
7x38 7.39x38 L288