PDB
7F6H
Resolution
2.9 Å
Released
Jan. 5, 2022
Receptor
B2
Class
A
Species
Homo sapiens
Ligand
bradykinin (Human)
Function
Agonist
Reference
10.1038/S41467-022-28399-1

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Ligand Amino Acid Generic Number Segment Interaction Type
bradykinin (Human) W113 2.60x60 TM2 hydrophobic
bradykinin (Human) F121 ECL1 hydrophobic
bradykinin (Human) I137 3.32x32 TM3 hydrophobic
bradykinin (Human) L141 3.36x36 TM3 hydrophobic
bradykinin (Human) R196 4.64x65 TM4 polar (charge-assisted hydrogen bond)
bradykinin (Human) Y201 ECL2 aromatic (face-to-edge)
bradykinin (Human) Y201 ECL2 Van der Waals
bradykinin (Human) A210 ECL2 hydrophobic
bradykinin (Human) V212 45.51x51 ECL2 Van der Waals
bradykinin (Human) V212 45.51x51 ECL2 hydrophobic
bradykinin (Human) I213 45.52x52 ECL2 Van der Waals
bradykinin (Human) I213 45.52x52 ECL2 polar (hydrogen bond with backbone)
bradykinin (Human) Y215 ECL2 hydrophobic
bradykinin (Human) L228 5.42x43 TM5 Van der Waals
bradykinin (Human) L228 5.42x43 TM5 hydrophobic
bradykinin (Human) F286 6.51x51 TM6 aromatic (face-to-edge)
bradykinin (Human) F286 6.51x51 TM6 Van der Waals
bradykinin (Human) S289 6.54x54 TM6 Van der Waals
bradykinin (Human) T290 6.55x55 TM6 Van der Waals
bradykinin (Human) T290 6.55x55 TM6 polar (hydrogen bond)
bradykinin (Human) D293 6.58x58 TM6 polar (charge-assisted hydrogen bond)
bradykinin (Human) R297 6.62x62 TM6 polar (charge-assisted hydrogen bond)
bradykinin (Human) D311 7.32x31 TM7 polar (charge-assisted hydrogen bond)
bradykinin (Human) Q315 7.36x35 TM7 Van der Waals
bradykinin (Human) S318 7.39x38 TM7 Van der Waals
bradykinin (Human) F319 7.40x39 TM7 hydrophobic
bradykinin (Human) A321 7.42x41 TM7 Van der Waals
bradykinin (Human) Y322 7.43x42 TM7 aromatic (face-to-edge)
bradykinin (Human) Y322 7.43x42 TM7 Van der Waals

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ICL1 K S S C ICL1ECL1 F D W L F ECL1ICL2 T M S M G R M R ICL2ECL2 T M K E Y S D E G H N V T A C V I S Y P ECL2ICL3 F K E ICL3ECL3 I L S ECL3N-term M F S P W K I S M F L S V R E D S V P T T A S F S A D M L N V T L Q G P T L N G T F A Q S K C P Q V E W L G N-termC-term Y Q G V C Q K G G C R S E P I Q M E N S M G T L R T S I S V E R Q I H K L Q D W A G S R Q C-term W L N T I Q P P F L W V L F V L A T L E N I F V L S V F C L H T V A E I Y L G N L A A A D L I L A C G L P F W A I T I S N N G E T L C R V V N A I I S M N L Y S S I C F L M L V S I D R Y L A L V K G V R W A K L Y S L V I W G C T L L L S S P M L V F R S L I W E V F T N M L L N V V G F L L P L S V I T F C T M Q I M Q V L R N N E M Q K I Q T E R R A T V L V L V V L L L F I I C W L P F Q I S T F L D T L H R L G S C Q D E R I I D V I T Q I A S F M A Y S N S C L N P L V Y V I V G K R S W E F R K K V
Helix box plot — Download: PNG | SVG I N E L T A L V F L V W L F P P Q I T N 1 G N L A A A D L I L A C G L P F W A I T 2 L M L F C I S S Y L N M S I I A N V V R 3 A K L Y S L V I W G C T L L L S S P M 4 T C F T I V S L P L L F G V V N L L M N T 5 L V V L L L F I I C W L P F Q I S T F L 6 L P N L C S N S Y A M F S A I Q T I V 7

GPCRdb(A)
GPCRdb(A)
B2 receptor
TM2
2x60 2.60x60 W113
TM3
3x32 3.32x32 I137
3x36 3.36x36 L141
TM4
4x65 4.64x65 R196
ECL2
45x51 45.51x51 V212
45x52 45.52x52 I213
TM5
5x43 5.42x43 L228
TM6
6x51 6.51x51 F286
6x54 6.54x54 S289
6x55 6.55x55 T290
6x58 6.58x58 D293
6x62 6.62x62 R297
TM7
7x31 7.32x31 D311
7x35 7.36x35 Q315
7x38 7.39x38 S318
7x39 7.40x39 F319
7x41 7.42x41 A321
7x42 7.43x42 Y322