Structure information

B2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7F6I

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-022-28399-1

PUBLICATION DATE

Jan. 5, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
kallidin W113 2.60x60 TM2 hydrophobic
kallidin F121 ECL1 hydrophobic
kallidin L141 3.36x36 TM3 hydrophobic
kallidin R196 ECL2 polar (charge-assisted hydrogen bond)
kallidin K199 ECL2 Van der Waals
kallidin Y201 ECL2 Van der Waals
kallidin Y201 ECL2 aromatic (face-to-edge)
kallidin E204 ECL2 Van der Waals
kallidin C211 45.50x50 ECL2 Van der Waals
kallidin C211 45.50x50 ECL2 polar (hydrogen bond with backbone)
kallidin V212 45.51x51 ECL2 Van der Waals
kallidin V212 45.51x51 ECL2 hydrophobic
kallidin I213 45.52x52 ECL2 polar (hydrogen bond with backbone)
kallidin I213 45.52x52 ECL2 Van der Waals
kallidin N225 5.39x40 TM5 Van der Waals
kallidin L228 5.42x43 TM5 hydrophobic
kallidin W283 6.48x48 TM6 hydrophobic
kallidin F286 6.51x51 TM6 Van der Waals
kallidin F286 6.51x51 TM6 aromatic (face-to-edge)
kallidin S289 6.54x54 TM6 Van der Waals
kallidin T290 6.55x55 TM6 Van der Waals
kallidin D293 6.58x58 TM6 polar (charge-assisted hydrogen bond)
kallidin H296 6.61x61 TM6 Van der Waals
kallidin R297 6.62x62 TM6 Van der Waals
kallidin E307 7.28x27 TM7 Van der Waals
kallidin D311 7.32x31 TM7 Van der Waals
kallidin T314 7.35x34 TM7 Van der Waals
kallidin T314 7.35x34 TM7 polar (hydrogen bond)
kallidin Q315 7.36x35 TM7 polar (hydrogen bond)
kallidin Q315 7.36x35 TM7 Van der Waals
kallidin S318 7.39x38 TM7 polar (hydrogen bond)
kallidin F319 7.40x39 TM7 hydrophobic
kallidin F319 7.40x39 TM7 Van der Waals
kallidin Y322 7.43x42 TM7 hydrophobic
kallidin Y322 7.43x42 TM7 Van der Waals

Ligands

kallidin

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Residue Diagrams

I N E L T A L V F L V W L F P P Q I T N 1 G N L A A A D L I L A C G L P F W A I T 2 L M L F C I S S Y L N M S I I A N V V R 3 A K L Y S L V I W G C T L L L S S P M 4 T C F T I V S L P L L F G V V N L L M N T 5 L V V L L L F I I C W L P F Q I S T F L 6 L P N L C S N S Y A M F S A I Q T I V 7
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ICL1 K S S C ICL1ECL1 F D W L F ECL1ICL2 T M S M G R M R ICL2ECL2 T M K E Y S D E G H N V T A C V I S Y P ECL2ICL3 F K E ICL3ECL3 I L S ECL3N-term M F S P W K I S M F L S V R E D S V P T T A S F S A D M L N V T L Q G P T L N G T F A Q S K C P Q V E W L G N-termC-term Y Q G V C Q K G G C R S E P I Q M E N S M G T L R T S I S V E R Q I H K L Q D W A G S R Q C-term W L N T I Q P P F L W V L F V L A T L E N I F V L S V F C L H T V A E I Y L G N L A A A D L I L A C G L P F W A I T I S N N G E T L C R V V N A I I S M N L Y S S I C F L M L V S I D R Y L A L V K G V R W A K L Y S L V I W G C T L L L S S P M L V F R S L I W E V F T N M L L N V V G F L L P L S V I T F C T M Q I M Q V L R N N E M Q K I Q T E R R A T V L V L V V L L L F I I C W L P F Q I S T F L D T L H R L G S C Q D E R I I D V I T Q I A S F M A Y S N S C L N P L V Y V I V G K R S W E F R K K V
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Residue Table


GPCRdb(A)
GPCRdb(A)
B2 receptor
TM2
2x60 2.60x60 W113
TM3
3x36 3.36x36 L141
ECL2
45x50 45.50x50 C211
45x51 45.51x51 V212
45x52 45.52x52 I213
TM5
5x40 5.39x40 N225
5x43 5.42x43 L228
TM6
6x48 6.48x48 W283
6x51 6.51x51 F286
6x54 6.54x54 S289
6x55 6.55x55 T290
6x58 6.58x58 D293
6x61 6.61x61 H296
6x62 6.62x62 R297
TM7
7x27 7.28x27 E307
7x31 7.32x31 D311
7x34 7.35x34 T314
7x35 7.36x35 Q315
7x38 7.39x38 S318
7x39 7.40x39 F319
7x42 7.43x42 Y322