PDB
7F8Y
Resolution
2.5 Å
Released
Oct. 13, 2021
Receptor
CCK1
Class
A
Species
Homo sapiens
Ligand
devazepide
Function
Antagonist
Reference
10.1038/S41589-021-00866-8

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
devazepide M121 3.32x32 TM3 hydrophobic
devazepide Y176 4.60x61 TM4 hydrophobic
devazepide I329 6.51x51 TM6 hydrophobic
devazepide F330 6.52x52 TM6 aromatic (face-to-edge)
devazepide A332 6.54x54 TM6 hydrophobic
devazepide N333 6.55x55 TM6 polar (hydrogen bond)
devazepide R336 6.58x58 TM6 polar (charge-assisted hydrogen bond)
devazepide A343 ECL3 hydrophobic
devazepide A343 ECL3 Van der Waals
devazepide E344 ECL3 Van der Waals
devazepide L347 ECL3 Van der Waals
devazepide L347 ECL3 hydrophobic
devazepide S348 ECL3 Van der Waals
devazepide I352 7.35x34 TM7 Van der Waals
devazepide I352 7.35x34 TM7 hydrophobic

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 K R M R ICL1ECL1 D F I F ECL1ICL2 P L Q S R V W Q ICL2ECL2 N L V P F T K N N N Q T A N M C R F L L P ECL2ICL3 Q K K S A K E R K P S T T S S G K Y E D S D G C Y L Q K T R P P R K L E L R Q L S T G S S S R A N R I R S N S ICL3ECL3 T A S A E R R L S ECL3N-term M D V V D S L L V N G S N I T P P C E L G L E N E T L F C L D Q P R P S K E N-termC-term P G P P G A R G E V G E E E E G G T T G A S L S R F S Y S H M S A S V P P Q C-term W Q P A V Q I L L Y S L I F L L S V L G N T L V I T V L I R N T V T N I F L L S L A V S D L M L C L F C M P F N L I P N L L K G S A V C K T T T Y F M G T S V S V S T F N L V A I S L E R Y G A I C K T K S H A L K V I A A T W C L S F T I M T P Y P I Y S N D V M Q Q S W H T F L L L I L F L I P G I V M M V A Y G L I S L E L Y Q G I K F E A S S A A N L M A K K R V I R M L I V I V V L F F L C W M P I F S A N A W R A Y D G T P I S F I L L L S Y T S S C V N P I I Y C F M N K R F M A C P N F R L G T F P C
Helix box plot — Download: PNG | SVG T N G L V S L L F I L S Y L L I Q V A P 1 L S L A V S D L M L C F L C M P F N L I P 2 A V L N F T S V S V S T G M F Y T T T K 3 A L K V I A A T W C L S F T I M T P Y 4 Y A V M M V I G P I L F L I L L L F T H W 5 I V I V V L F F L C W M P I F S A N A W 6 I P N V C S S T Y S L L L I F S I P T 7

GPCRdb(A)
GPCRdb(A)
CCK1 receptor
TM3
3x32 3.32x32 M121
TM4
4x61 4.60x61 Y176
TM6
6x51 6.51x51 I329
6x52 6.52x52 F330
6x54 6.54x54 A332
6x55 6.55x55 N333
6x58 6.58x58 R336
TM7
7x34 7.35x34 I352