PDB
7FIG
Resolution
3.9 Å
Released
Sept. 29, 2021
Receptor
LH
Class
A
Species
Homo sapiens
Ligands
Choriogonadotropin subunit beta 3
Glycoprotein hormones alpha chain
Function
Agonist
Agonist
Reference
10.1038/S41586-021-03924-2
Choriogonadotropin subunit beta 3 Glycoprotein hormones alpha chain

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Ligand Amino Acid Generic Number Segment Interaction Type
Choriogonadotropin subunit beta 3 Y58 N-term polar (hydrogen bond)
Choriogonadotropin subunit beta 3 E79 N-term polar (charge-assisted hydrogen bond)
Choriogonadotropin subunit beta 3 S81 N-term polar (hydrogen bond)
Choriogonadotropin subunit beta 3 S81 N-term Van der Waals
Choriogonadotropin subunit beta 3 Q82 N-term Van der Waals
Choriogonadotropin subunit beta 3 Q82 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain E102 N-term polar (charge-assisted hydrogen bond)
Choriogonadotropin subunit beta 3 Q106 N-term polar (hydrogen bond)
Choriogonadotropin subunit beta 3 Q106 N-term Van der Waals
Glycoprotein hormones alpha chain N107 N-term Van der Waals
Glycoprotein hormones alpha chain T108 N-term Van der Waals
Glycoprotein hormones alpha chain K109 N-term polar (hydrogen bond with backbone)
Glycoprotein hormones alpha chain K109 N-term Van der Waals
Glycoprotein hormones alpha chain Y127 N-term Van der Waals
Glycoprotein hormones alpha chain Y127 N-term hydrophobic
Glycoprotein hormones alpha chain C131 N-term Van der Waals
Glycoprotein hormones alpha chain N132 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain N132 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain E148 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain S149 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain S149 N-term polar (hydrogen bond)
Choriogonadotropin subunit beta 3 N150 N-term Van der Waals
Glycoprotein hormones alpha chain N150 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain N150 N-term Van der Waals
Choriogonadotropin subunit beta 3 N150 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain I152 N-term hydrophobic
Glycoprotein hormones alpha chain I152 N-term Van der Waals
Glycoprotein hormones alpha chain E154 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain C156 N-term polar (hydrogen bond)
Choriogonadotropin subunit beta 3 D157 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain D157 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain H160 N-term Van der Waals
Glycoprotein hormones alpha chain E175 N-term Van der Waals
Glycoprotein hormones alpha chain K180 N-term polar (charge-assisted hydrogen bond)
Choriogonadotropin subunit beta 3 Y182 N-term Van der Waals
Choriogonadotropin subunit beta 3 Y182 N-term hydrophobic
Glycoprotein hormones alpha chain Y182 N-term Van der Waals
Glycoprotein hormones alpha chain Y182 N-term hydrophobic
Choriogonadotropin subunit beta 3 G183 N-term Van der Waals
Choriogonadotropin subunit beta 3 E206 N-term polar (charge-assisted hydrogen bond)
Choriogonadotropin subunit beta 3 K225 N-term polar (charge-assisted hydrogen bond)
Choriogonadotropin subunit beta 3 R247 N-term Van der Waals
Glycoprotein hormones alpha chain W329 N-term hydrophobic
Glycoprotein hormones alpha chain W329 N-term Van der Waals
Glycoprotein hormones alpha chain D330 N-term Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 R Y K L ICL1ECL1 K G Q Y Y N H A I D W Q T ECL1ICL2 A I H L D Q K L ICL2ECL2 V S N Y M K V S I C F P M D V E ECL2ICL3 N P E L M ICL3ECL3 V P L I ECL3N-term M K Q R F S A L Q L L K L L L L L Q P P L P R A L R E A L C P E P C N C V P D G A L R C P G P T A G L T R L S L A Y L P V K V I P S Q A F R G L N E V I K I E I S Q I D S L E R I E A N A F D N L L N L S E I L I Q N T K N L R Y I E P G A F I N L P R L K Y L S I C N T G I R K F P D V T K V F S S E S N F I L E I C D N L H I T T I P G N A F Q G M N N E S V T L K L Y G N G F E E V Q S H A F N G T T L T S L E L K E N V H L E K M H N G A F R G A T G P K T L D I S S T K L Q A L P S Y G L E S I Q R L I A T S S Y S L K K L P S R E T F V N L L E A T L T Y P S H C C A F R N L P T K E Q N F S H S I S E N F S K Q C E S T V R K V N N K T L Y S S M L A E S E L S G W D Y E Y G F C L P K T P R C A P E P D A F N P C E D I M G N-termC-term G C C K R R A E L Y R R K D F S A Y T S N C K N G F T G S N K P S Q S T L K L S T L H C Q G T A L L D K T R Y T E C C-term Y D F L R V L I W L I N I L A I M G N M T V L F V L L T S T V P R F L M C N L S F A D F C M G L Y L L L I A S V D S Q T G S G C S T A G F F T V F A S E L S V Y T L T V I T L E R W H T I T Y R L R H A I L I M L G G W L F S S L I A M L P L V G T T L S Q V Y I L T I L I L N V V A F F I I C A C Y I K I Y F A V R A T N K D T K I A K K M A I L I F T D F T C M A P I S F F A I S A A F K T V T N S K V L L V L F Y P I N S C A N P F L Y A I F T K T F F L F F Q R D L L S K
Helix box plot — Download: PNG | SVG M N G M I A L I N I L W I L V R L F D Y 1 C N L S F A D F C M G L Y L L L I A S V 2 V T L T Y V S L E S A F V T F F G A T S 3 A I L I M L G G W L F S S L I A M L P L 4 Y C A C I I F F A V V N L I L I T L I Y 5 A I L I F T D F T C M A P I S F F A I S 6 F P N A C S N I P Y F L V L L V K S N 7

GPCRdb(A)
GPCRdb(A)
LH receptor