PDB
7FIH
Resolution
3.2 Å
Released
Sept. 29, 2021
Receptor
LH
Class
A
Species
Homo sapiens
Ligands
Chorionic gonadotropin beta subunit
Chorionic gonadotropin alpha subunit
Org43553
Function
Agonist
Agonist
Allosteric agonist
Reference
10.1038/S41586-021-03924-2
Chorionic gonadotropin beta subunit Chorionic gonadotropin alpha subunit Org43553

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Ligand Amino Acid Generic Number Segment Interaction Type
Chorionic gonadotropin beta subunit Y58 N-term Van der Waals
Chorionic gonadotropin beta subunit Y58 N-term polar (hydrogen bond)
Chorionic gonadotropin beta subunit E79 N-term Van der Waals
Chorionic gonadotropin beta subunit Q82 N-term Van der Waals
Chorionic gonadotropin alpha subunit E102 N-term polar (charge-assisted hydrogen bond)
Chorionic gonadotropin beta subunit Q106 N-term polar (hydrogen bond)
Chorionic gonadotropin beta subunit Q106 N-term Van der Waals
Chorionic gonadotropin alpha subunit N107 N-term Van der Waals
Chorionic gonadotropin alpha subunit K109 N-term polar (charge-assisted hydrogen bond)
Chorionic gonadotropin alpha subunit K126 N-term polar (charge-assisted hydrogen bond)
Chorionic gonadotropin alpha subunit Y127 N-term aromatic (face-to-face)
Chorionic gonadotropin alpha subunit N132 N-term Van der Waals
Chorionic gonadotropin alpha subunit T133 N-term Van der Waals
Chorionic gonadotropin alpha subunit G134 N-term Van der Waals
Chorionic gonadotropin alpha subunit E148 N-term Van der Waals
Chorionic gonadotropin alpha subunit S149 N-term polar (hydrogen bond)
Chorionic gonadotropin beta subunit N150 N-term Van der Waals
Chorionic gonadotropin alpha subunit N150 N-term polar (hydrogen bond)
Chorionic gonadotropin alpha subunit N150 N-term Van der Waals
Chorionic gonadotropin alpha subunit I152 N-term Van der Waals
Chorionic gonadotropin alpha subunit E154 N-term polar (charge-assisted hydrogen bond)
Chorionic gonadotropin beta subunit D157 N-term polar (charge-assisted hydrogen bond)
Chorionic gonadotropin alpha subunit T178 N-term Van der Waals
Chorionic gonadotropin alpha subunit K180 N-term Van der Waals
Chorionic gonadotropin beta subunit Y182 N-term hydrophobic
Chorionic gonadotropin alpha subunit Y182 N-term Van der Waals
Chorionic gonadotropin beta subunit Y182 N-term Van der Waals
Chorionic gonadotropin beta subunit G183 N-term Van der Waals
Chorionic gonadotropin alpha subunit K205 N-term polar (charge-assisted hydrogen bond)
Chorionic gonadotropin beta subunit E206 N-term polar (charge-assisted hydrogen bond)
Chorionic gonadotropin beta subunit K225 N-term Van der Waals
Chorionic gonadotropin beta subunit R247 N-term Van der Waals
Org43553 F350 N-term hydrophobic
Org43553 F515 45.51x51 ECL2 hydrophobic
Org43553 P516 45.52x52 ECL2 Van der Waals
Org43553 P516 45.52x52 ECL2 polar (hydrogen bond with backbone)
Org43553 M517 ECL2 Van der Waals
Org43553 M517 ECL2 hydrophobic
Org43553 I528 5.40x40 TM5 Van der Waals
Org43553 A589 6.55x55 TM6 hydrophobic
Org43553 A589 6.55x55 TM6 Van der Waals
Org43553 A592 6.58x58 TM6 Van der Waals
Org43553 A592 6.58x58 TM6 hydrophobic
Org43553 K595 6.61x61 TM6 polar (charge-assisted hydrogen bond)
Org43553 P597 ECL3 hydrophobic
Org43553 P597 ECL3 Van der Waals
Org43553 I599 ECL3 Van der Waals
Org43553 V601 7.31x30 TM7 hydrophobic
Org43553 V601 7.31x30 TM7 Van der Waals
Org43553 S604 7.34x33 TM7 polar (hydrogen bond)
Org43553 Y612 7.42x41 TM7 Van der Waals

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NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

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Snake plot — Download: PNG | SVG
ICL1 R Y K L ICL1ECL1 K G Q Y Y N H A I D W Q T ECL1ICL2 A I H L D Q K L ICL2ECL2 V S N Y M K V S I C F P M D V E ECL2ICL3 N P E L M ICL3ECL3 V P L I ECL3N-term M K Q R F S A L Q L L K L L L L L Q P P L P R A L R E A L C P E P C N C V P D G A L R C P G P T A G L T R L S L A Y L P V K V I P S Q A F R G L N E V I K I E I S Q I D S L E R I E A N A F D N L L N L S E I L I Q N T K N L R Y I E P G A F I N L P R L K Y L S I C N T G I R K F P D V T K V F S S E S N F I L E I C D N L H I T T I P G N A F Q G M N N E S V T L K L Y G N G F E E V Q S H A F N G T T L T S L E L K E N V H L E K M H N G A F R G A T G P K T L D I S S T K L Q A L P S Y G L E S I Q R L I A T S S Y S L K K L P S R E T F V N L L E A T L T Y P S H C C A F R N L P T K E Q N F S H S I S E N F S K Q C E S T V R K V N N K T L Y S S M L A E S E L S G W D Y E Y G F C L P K T P R C A P E P D A F N P C E D I M G N-termC-term G C C K R R A E L Y R R K D F S A Y T S N C K N G F T G S N K P S Q S T L K L S T L H C Q G T A L L D K T R Y T E C C-term Y D F L R V L I W L I N I L A I M G N M T V L F V L L T S T V P R F L M C N L S F A D F C M G L Y L L L I A S V D S Q T G S G C S T A G F F T V F A S E L S V Y T L T V I T L E R W H T I T Y R L R H A I L I M L G G W L F S S L I A M L P L V G T T L S Q V Y I L T I L I L N V V A F F I I C A C Y I K I Y F A V R A T N K D T K I A K K M A I L I F T D F T C M A P I S F F A I S A A F K T V T N S K V L L V L F Y P I N S C A N P F L Y A I F T K T F F L F F Q R D L L S K
Helix box plot — Download: PNG | SVG M N G M I A L I N I L W I L V R L F D Y 1 C N L S F A D F C M G L Y L L L I A S V 2 V T L T Y V S L E S A F V T F F G A T S 3 A I L I M L G G W L F S S L I A M L P L 4 Y C A C I I F F A V V N L I L I T L I Y 5 A I L I F T D F T C M A P I S F F A I S 6 F P N A C S N I P Y F L V L L V K S N 7

GPCRdb(A)
GPCRdb(A)
LH receptor
ECL2
45x51 45.51x51 F515
45x52 45.52x52 P516
TM5
5x40 5.40x40 I528
TM6
6x55 6.55x55 A589
6x58 6.58x58 A592
6x61 6.61x61 K595
TM7
7x30 7.31x30 V601
7x33 7.34x33 S604
7x41 7.42x41 Y612