PDB
7JVP
Resolution
2.9 Å
Released
Feb. 24, 2021
Receptor
D1
Class
A
Species
Homo sapiens
Ligand
SKF-83959
Function
Agonist (partial)
Reference
10.1016/J.CELL.2021.01.027

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Ligand Amino Acid Generic Number Segment Interaction Type
SKF-83959 D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
SKF-83959 I104 3.33x33 TM3 Van der Waals
SKF-83959 I104 3.33x33 TM3 hydrophobic
SKF-83959 S107 3.36x36 TM3 Van der Waals
SKF-83959 S188 45.52x52 ECL2 Van der Waals
SKF-83959 L190 ECL2 Van der Waals
SKF-83959 L190 ECL2 hydrophobic
SKF-83959 S198 5.42x43 TM5 polar (hydrogen bond)
SKF-83959 S198 5.42x43 TM5 polar (hydrogen bond with backbone)
SKF-83959 S202 5.46x461 TM5 polar (hydrogen bond)
SKF-83959 F288 6.51x51 TM6 aromatic (edge-to-face)
SKF-83959 F288 6.51x51 TM6 Van der Waals
SKF-83959 F289 6.52x52 TM6 hydrophobic
SKF-83959 F289 6.52x52 TM6 Van der Waals
SKF-83959 N292 6.55x55 TM6 Van der Waals
SKF-83959 N292 6.55x55 TM6 polar (hydrogen bond)
SKF-83959 F313 7.35x34 TM7 Van der Waals
SKF-83959 F313 7.35x34 TM7 hydrophobic
SKF-83959 V317 7.39x38 TM7 hydrophobic
SKF-83959 V317 7.39x38 TM7 Van der Waals
SKF-83959 W321 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
Helix box plot — Download: PNG | SVG T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7

GPCRdb(A)
GPCRdb(A)
D1 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
ECL2
45x52 45.52x52 S188
TM5
5x43 5.42x43 S198
5x461 5.46x461 S202
TM6
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 N292
TM7
7x34 7.35x34 F313
7x38 7.39x38 V317
7x42 7.43x42 W321