PDB
7L0P
Resolution
4.1 Å
Released
Jan. 6, 2021
Receptor
NTS1
Class
A
Species
Rattus norvegicus
Ligand
NTS8–13
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
NTS8–13 L55 N-term polar (hydrogen bond with backbone)
NTS8–13 L55 N-term Van der Waals
NTS8–13 F128 ECL1 Van der Waals
NTS8–13 F128 ECL1 hydrophobic
NTS8–13 H133 ECL1 polar (hydrogen bond)
NTS8–13 Y146 3.29x29 TM3 polar (hydrogen bond)
NTS8–13 V224 ECL2 Van der Waals
NTS8–13 V224 ECL2 hydrophobic
NTS8–13 T226 45.51x51 ECL2 Van der Waals
NTS8–13 T231 5.32x33 TM5 Van der Waals
NTS8–13 R327 6.54x54 TM6 polar (charge-assisted hydrogen bond)
NTS8–13 R328 6.55x55 TM6 Van der Waals
NTS8–13 F331 6.58x58 TM6 Van der Waals
NTS8–13 F331 6.58x58 TM6 hydrophobic
NTS8–13 C332 6.59x59 TM6 Van der Waals
NTS8–13 I334 6.61x61 TM6 polar (hydrogen bond with backbone)
NTS8–13 I334 6.61x61 TM6 Van der Waals
NTS8–13 S335 ECL3 Van der Waals
NTS8–13 D336 ECL3 polar (charge-assisted hydrogen bond)
NTS8–13 W339 ECL3 Van der Waals
NTS8–13 W339 ECL3 hydrophobic
NTS8–13 F344 7.28x27 TM7 hydrophobic
NTS8–13 F344 7.28x27 TM7 Van der Waals
NTS8–13 Y347 7.31x30 TM7 polar (hydrogen bond)
NTS8–13 Y347 7.31x30 TM7 Van der Waals
NTS8–13 Y351 7.35x34 TM7 Van der Waals
NTS8–13 Y351 7.35x34 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G L Q N R S G D G T H P G G L V C T P I V D ECL2ICL3 R V C T V G T H N G L E H S T F N M T I E ICL3ECL3 S D E Q W ECL3N-term M H L N S S V P Q G T P G E P D A Q P F S G P Q S E M E A T F L A L S L S N G S G N T S E S D T A G P N S D L D V N T D N-termC-term P G W R H R R K K R P T F S R K P N S M S S N H A F S T S A T R E T L Y C-term I Y S K V L V T A I Y L A L F V V G T V G N S V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L I L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A I P M L F T M T A T V K V V I Q V N T F M S F L F P M L V I S I L N T V I A N K L T V M V H Q A A E Q G P G R V Q A L R H G V L V L R A V V I A F V V C W L P Y H V R R L M F C Y I T T F L F D F Y H Y F Y M L T N A L F Y V S S A I N P I L Y N L V S A N F L S L C F R Q V T L A C
Helix box plot — Download: PNG | SVG S N G V T G V V F L A L Y I A T V L V K 1 G S L A L S D L L I L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A I P M 4 N L I S I V L M P F L F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I A S S V Y F L A N T L M Y F Y 7

GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM3
3x29 3.29x29 Y146
ECL2
45x51 45.51x51 T226
TM5
5x33 5.32x33 T231
TM6
6x54 6.54x54 R327
6x55 6.55x55 R328
6x58 6.58x58 F331
6x59 6.59x59 C332
6x61 6.61x61 I334
TM7
7x27 7.28x27 F344
7x30 7.31x30 Y347
7x34 7.35x34 Y351