PDB
7L1U
Resolution
3.2 Å
Released
Feb. 10, 2021
Receptor
OX2
Class
A
Species
Homo sapiens
Ligand
Function
orexin-B (Human)
Agonist
Reference
10.1038/S41467-021-21087-6

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Ligand Amino Acid Generic Number Segment Interaction Type
orexin-B (Human) C107 2.57x56 TM2 Van der Waals
orexin-B (Human) V114 2.64x63 TM2 Van der Waals
orexin-B (Human) W120 23.50x50 ECL1 hydrophobic
orexin-B (Human) P131 3.29x29 TM3 hydrophobic
orexin-B (Human) Q134 3.32x32 TM3 Van der Waals
orexin-B (Human) T135 3.33x33 TM3 Van der Waals
orexin-B (Human) V138 3.36x36 TM3 Van der Waals
orexin-B (Human) V138 3.36x36 TM3 hydrophobic
orexin-B (Human) Q187 4.60x61 TM4 Van der Waals
orexin-B (Human) V209 ECL2 Van der Waals
orexin-B (Human) C210 45.50x50 ECL2 Van der Waals
orexin-B (Human) D211 45.51x51 ECL2 polar (hydrogen bond)
orexin-B (Human) F227 5.42x43 TM5 hydrophobic
orexin-B (Human) T231 5.46x461 TM5 hydrophobic
orexin-B (Human) I320 6.51x51 TM6 hydrophobic
orexin-B (Human) N324 6.55x55 TM6 polar (hydrogen bond)
orexin-B (Human) K327 6.58x58 TM6 Van der Waals
orexin-B (Human) F333 ECL3 hydrophobic
orexin-B (Human) A334 ECL3 Van der Waals
orexin-B (Human) T336 ECL3 Van der Waals
orexin-B (Human) R339 7.28x27 TM7 hydrophobic
orexin-B (Human) V342 7.31x30 TM7 Van der Waals
orexin-B (Human) Y343 7.32x31 TM7 hydrophobic
orexin-B (Human) F346 7.35x34 TM7 hydrophobic
orexin-B (Human) H350 7.39x38 TM7 Van der Waals
orexin-B (Human) Y354 7.43x42 TM7 Van der Waals

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ICL1 H H M R ICL1ECL1 T W F F ECL1ICL2 P L M F K S ICL2ECL2 E C S T V F P G L A N K T T L F T V C D E R W G G E ECL2ICL3 G T S S V V Q R K W K P L Q P V S Q P R G P G Q P T K S R M S A ICL3ECL3 G M F A H T E ECL3N-term M S G T K L E D S P P C R N W S S A S E L N E T Q E P F L N P T D Y D D E E F L R Y L W R E Y L H P K E N-termC-term G V H H R Q E D R L T R G R T S T E S R K S L T T Q I S N F D N I S K L S E Q V V L T S I S T L P A A N G A G P L Q N W C-term Y E W V L I A G Y I I V F V V A L I G N V L V C V A V W K N T V T N Y F I V N L S L A D V L V T I T C L P A T L V V D I T E G Q S L C K V I P Y L Q T V S V S V S V L T L S C I A L D R W Y A I C H T A K R A R N S I V I I W I V S C I I M I P Q A I V M I Y P K M Y H I C F F L V T Y M A P L C L M V L A Y L Q I F R K L W C R Q I P V A A E I K Q I R A R R K T A R M L M I V L L V F A I C Y L P I S I L N V L K R V F D R E T V Y A W F T F S H W L V Y A N S A A N P I I Y N F L S G K F K A C C L F R E E A F S C
Helix box plot — Download: PNG | SVG V N G I L A V V F V I I Y G A I L V W E 1 V N L S L A D V L V T T I C L P A T L V V 2 C S L T L V S V S V S V T Q L Y P I V K 3 A R N S I V I I W I V S C I I M I P Q 4 Y A L V M L C L P A M Y T V L F F C I H Y 5 M I V L L V F A I C Y L P I S I L N V L 6 I P N A A S N A Y V L W H S F T F W A 7

GPCRdb(A)
GPCRdb(A)
OX2 receptor
TM2
2x56 2.57x56 C107
2x63 2.64x63 V114
ECL1
23x50 23.50x50 W120
TM3
3x29 3.29x29 P131
3x32 3.32x32 Q134
3x33 3.33x33 T135
3x36 3.36x36 V138
TM4
4x61 4.60x61 Q187
ECL2
45x50 45.50x50 C210
45x51 45.51x51 D211
TM5
5x43 5.42x43 F227
5x461 5.46x461 T231
TM6
6x51 6.51x51 I320
6x55 6.55x55 N324
6x58 6.58x58 K327
TM7
7x27 7.28x27 R339
7x30 7.31x30 V342
7x31 7.32x31 Y343
7x34 7.35x34 F346
7x38 7.39x38 H350
7x42 7.43x42 Y354