Structure information

A1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7LD3

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-021-03897-2

PUBLICATION DATE

Sept. 8, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone L18 1.41x41 TM1 hydrophobic
{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone I19 1.42x42 TM1 hydrophobic
{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone S246 6.47x47 TM6 polar (hydrogen bond)
{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone S246 6.47x47 TM6 Van der Waals
{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone F275 7.40x39 TM7 polar (hydrogen bond with backbone)
{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone F275 7.40x39 TM7 Van der Waals
{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone L276 7.41x40 TM7 polar (hydrogen bond with backbone)
{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone L276 7.41x40 TM7 Van der Waals
{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone G279 7.44x43 TM7 polar (hydrogen bond with backbone)
{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone G279 7.44x43 TM7 Van der Waals
{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone N280 7.45x45 TM7 polar (hydrogen bond with backbone)
{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone N280 7.45x45 TM7 Van der Waals
{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone A282 7.47x47 TM7 Van der Waals
{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone M283 7.48x48 TM7 polar (hydrogen bond)

Ligands

{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone

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Residue Diagrams

V N G P V S V L A I L V E I G I Y A A Q 1 V S L A V A D V A V G L A V I P L A I L I 2 A L L A L I S S Q T L I L V P C A V M L 3 A A V A I A G C W I L S F V V G L T P M 4 Y I L V M L L L P P L V W V F F N F Y V M Y 5 A L I L F L F A L S W L P L H I L N C I 6 I P N M A S N G H T L F I A I Y T L I 7
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ICL1 Q A L R ICL1ECL1 P Q T ECL1ICL2 P L R Y K M V V ICL2ECL2 W N N L S A V E R A W A A N G S M G E P V I K C E F E K V I ECL2ICL3 S A S S G ICL3ECL3 P S C H K ECL3N-term M P P S I N-termC-term I D E D L P E E R P D D C-term S A F Q A A Y I G I E V L I A L V S V P G N V L V I W A V K V N D A T F C F I V S L A V A D V A V G A L V I P L A I L I N I G Y F H T C L M V A C P V L I L T Q S S I L A L L A I A V D R Y L R V K I T P R R A A V A I A G C W I L S F V V G L T P M F G S M E Y M V Y F N F F V W V L P P L L L M V L I Y L E V F Y L I R K Q L N K K V D P Q K Y Y G K E L K I A K S L A L I L F L F A L S W L P L H I L N C I T L F C P S I L T Y I A I F L T H G N S A M N P I V Y A F R I Q K F L K H F R P P F R V T I W N D C Q P A
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Residue Table


GPCRdb(A)
GPCRdb(A)
A1 receptor
TM1
1x41 1.41x41 L18
1x42 1.42x42 I19
TM6
6x47 6.47x47 S246
TM7
7x39 7.40x39 F275
7x40 7.41x40 L276
7x43 7.44x43 G279
7x45 7.45x45 N280
7x47 7.47x47 A282
7x48 7.48x48 M283