Structure information

D1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7LJC

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-021-00482-0

PUBLICATION DATE

March 3, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL1160787 D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
CHEMBL1160787 I104 3.33x33 TM3 Van der Waals
CHEMBL1160787 I104 3.33x33 TM3 hydrophobic
CHEMBL1160787 S107 3.36x36 TM3 Van der Waals
CHEMBL1160787 T108 3.37x37 TM3 Van der Waals
CHEMBL1160787 S188 45.52x52 ECL2 Van der Waals
CHEMBL1160787 L190 ECL2 Van der Waals
CHEMBL1160787 L190 ECL2 hydrophobic
CHEMBL1160787 S198 5.42x43 TM5 polar (hydrogen bond)
CHEMBL1160787 S202 5.46x461 TM5 Van der Waals
CHEMBL1160787 W285 6.48x48 TM6 Van der Waals
CHEMBL1160787 F288 6.51x51 TM6 aromatic (edge-to-face)
CHEMBL1160787 F288 6.51x51 TM6 Van der Waals
CHEMBL1160787 F289 6.52x52 TM6 hydrophobic
CHEMBL1160787 F289 6.52x52 TM6 Van der Waals
CHEMBL1160787 N292 6.55x55 TM6 polar (hydrogen bond)
CHEMBL1160787 N292 6.55x55 TM6 Van der Waals
CHEMBL1160787 F313 7.35x34 TM7 hydrophobic
CHEMBL1160787 F313 7.35x34 TM7 Van der Waals
CHEMBL1160787 W321 7.43x42 TM7 Van der Waals

Ligands

CHEMBL1160787

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Residue Diagrams

T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7
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ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
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Residue Table


GPCRdb(A)
GPCRdb(A)
D1 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
3x37 3.37x37 T108
ECL2
45x52 45.52x52 S188
TM5
5x43 5.42x43 S198
5x461 5.46x461 S202
TM6
6x48 6.48x48 W285
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 N292
TM7
7x34 7.35x34 F313
7x42 7.43x42 W321