Ligands
Function
Agonist
Ago-PAM
Reference
| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| SKF-81297 | D103 | 3.32x32 | TM3 | polar (charge-assisted hydrogen bond) |
| SKF-81297 | I104 | 3.33x33 | TM3 | hydrophobic |
| SKF-81297 | I104 | 3.33x33 | TM3 | Van der Waals |
| SKF-81297 | S107 | 3.36x36 | TM3 | Van der Waals |
| SKF-81297 | T108 | 3.37x37 | TM3 | Van der Waals |
| mevidalen | W123 | 3.52x52 | TM3 | aromatic (face-to-face) |
| mevidalen | R130 | 34.52x52 | ICL2 | polar (charge-assisted hydrogen bond) |
| mevidalen | Y131 | 34.53x53 | ICL2 | Van der Waals |
| mevidalen | K134 | 34.56x56 | ICL2 | Van der Waals |
| mevidalen | M135 | 34.57x57 | ICL2 | hydrophobic |
| mevidalen | M135 | 34.57x57 | ICL2 | Van der Waals |
| mevidalen | K138 | 4.40x40 | TM4 | polar (charge-assisted hydrogen bond) |
| mevidalen | A139 | 4.41x41 | TM4 | hydrophobic |
| mevidalen | A139 | 4.41x41 | TM4 | Van der Waals |
| mevidalen | I142 | 4.44x44 | TM4 | Van der Waals |
| mevidalen | I142 | 4.44x44 | TM4 | hydrophobic |
| mevidalen | L143 | 4.45x45 | TM4 | hydrophobic |
| SKF-81297 | S188 | 45.52x52 | ECL2 | Van der Waals |
| SKF-81297 | L190 | ECL2 | Van der Waals | |
| SKF-81297 | L190 | ECL2 | hydrophobic | |
| SKF-81297 | S198 | 5.42x43 | TM5 | polar (hydrogen bond) |
| SKF-81297 | S202 | 5.46x461 | TM5 | Van der Waals |
| SKF-81297 | F288 | 6.51x51 | TM6 | Van der Waals |
| SKF-81297 | F288 | 6.51x51 | TM6 | aromatic (edge-to-face) |
| SKF-81297 | F289 | 6.52x52 | TM6 | hydrophobic |
| SKF-81297 | F289 | 6.52x52 | TM6 | Van der Waals |
| SKF-81297 | N292 | 6.55x55 | TM6 | polar (hydrogen bond) |
| SKF-81297 | N292 | 6.55x55 | TM6 | Van der Waals |
| SKF-81297 | F313 | 7.35x34 | TM7 | Van der Waals |
| SKF-81297 | F313 | 7.35x34 | TM7 | hydrophobic |
| SKF-81297 | W321 | 7.43x42 | TM7 | Van der Waals |
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|
GPCRdb(A)
|
GPCRdb(A)
|
D1 receptor
|
|---|---|---|
| TM3 | ||
| 3x32 | 3.32x32 | D103 |
| 3x33 | 3.33x33 | I104 |
| 3x36 | 3.36x36 | S107 |
| 3x37 | 3.37x37 | T108 |
| 3x52 | 3.52x52 | W123 |
| ICL2 | ||
| 34x52 | 34.52x52 | R130 |
| 34x53 | 34.53x53 | Y131 |
| 34x56 | 34.56x56 | K134 |
| 34x57 | 34.57x57 | M135 |
| TM4 | ||
| 4x40 | 4.40x40 | K138 |
| 4x41 | 4.41x41 | A139 |
| 4x44 | 4.44x44 | I142 |
| 4x45 | 4.45x45 | L143 |
| ECL2 | ||
| 45x52 | 45.52x52 | S188 |
| TM5 | ||
| 5x43 | 5.42x43 | S198 |
| 5x461 | 5.46x461 | S202 |
| TM6 | ||
| 6x51 | 6.51x51 | F288 |
| 6x52 | 6.52x52 | F289 |
| 6x55 | 6.55x55 | N292 |
| TM7 | ||
| 7x34 | 7.35x34 | F313 |
| 7x42 | 7.43x42 | W321 |