PDB
7LJD
Resolution
3.2 Å
Released
March 3, 2021
Receptor
D1
Class
A
Species
Homo sapiens
Ligands
Function
dopamine
Agonist
mevidalen
Ago-PAM
Reference
10.1038/S41422-021-00482-0
dopamine mevidalen

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Ligand Amino Acid Generic Number Segment Interaction Type
dopamine D103 3.32x32 TM3 polar (hydrogen bond)
dopamine D103 3.32x32 TM3 polar (charge-charge)
dopamine I104 3.33x33 TM3 Van der Waals
dopamine S107 3.36x36 TM3 Van der Waals
dopamine T108 3.37x37 TM3 Van der Waals
mevidalen W123 3.52x52 TM3 hydrophobic
mevidalen W123 3.52x52 TM3 aromatic (face-to-face)
mevidalen S127 3.56x56 TM3 Van der Waals
mevidalen R130 34.52x52 ICL2 aromatic (pi-cation)
mevidalen R130 34.52x52 ICL2 polar (hydrogen bond)
mevidalen R130 34.52x52 ICL2 hydrophobic
mevidalen Y131 34.53x53 ICL2 Van der Waals
mevidalen K134 34.56x56 ICL2 hydrophobic
mevidalen M135 34.57x57 ICL2 hydrophobic
mevidalen K138 4.40x40 TM4 polar (hydrogen bond)
mevidalen A139 4.41x41 TM4 hydrophobic
mevidalen I142 4.44x44 TM4 hydrophobic
mevidalen L143 4.45x45 TM4 hydrophobic
dopamine L190 ECL2 Van der Waals
dopamine S198 5.42x43 TM5 polar (hydrogen bond)
dopamine S202 5.46x461 TM5 polar (hydrogen bond)
dopamine W285 6.48x48 TM6 Van der Waals
dopamine F288 6.51x51 TM6 hydrophobic
dopamine F289 6.52x52 TM6 hydrophobic
dopamine F289 6.52x52 TM6 aromatic (edge-to-face)
dopamine N292 6.55x55 TM6 polar (hydrogen bond)
dopamine V317 7.39x38 TM7 Van der Waals
dopamine W321 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
Helix box plot — Download: PNG | SVG T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7

GPCRdb(A)
GPCRdb(A)
D1 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
3x37 3.37x37 T108
3x52 3.52x52 W123
3x56 3.56x56 S127
ICL2
34x52 34.52x52 R130
34x53 34.53x53 Y131
34x56 34.56x56 K134
34x57 34.57x57 M135
TM4
4x40 4.40x40 K138
4x41 4.41x41 A139
4x44 4.44x44 I142
4x45 4.45x45 L143
TM5
5x43 5.42x43 S198
5x461 5.46x461 S202
TM6
6x48 6.48x48 W285
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 N292
TM7
7x38 7.39x38 V317
7x42 7.43x42 W321