PDB
7LLL
Resolution
3.7 Å
Released
Jan. 12, 2022
Receptor
GLP-1
Class
B1
Species
Homo sapiens
Ligand
Function
Exendin-4
Agonist
Reference
10.1038/S41467-021-27760-0

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Ligand Amino Acid Generic Number Segment Interaction Type
Exendin-4 V30 N-term Van der Waals
Exendin-4 L32 N-term Van der Waals
Exendin-4 W39 N-term Van der Waals
Exendin-4 E68 N-term hydrophobic
Exendin-4 Y69 N-term Van der Waals
Exendin-4 L89 N-term hydrophobic
Exendin-4 L141 1.36x36 TM1 hydrophobic
Exendin-4 L144 1.39x39 TM1 hydrophobic
Exendin-4 Y148 1.43x43 TM1 aromatic (edge-to-face)
Exendin-4 Y152 1.47x47 TM1 polar (hydrogen bond)
Exendin-4 R190 2.60x60 TM2 polar (charge-charge)
Exendin-4 K197 2.67x67 TM2 Van der Waals
Exendin-4 L201 2.71x71 TM2 Van der Waals
Exendin-4 Y205 2.75x75 TM2 polar (hydrogen bond)
Exendin-4 W214 ECL1 hydrophobic
Exendin-4 M233 3.36x36 TM3 Van der Waals
Exendin-4 Q234 3.37x37 TM3 Van der Waals
Exendin-4 V237 3.40x40 TM3 Van der Waals
Exendin-4 Y241 3.44x44 TM3 Van der Waals
Exendin-4 T298 45.52x52 ECL2 polar (hydrogen bond with backbone)
Exendin-4 T298 45.52x52 ECL2 polar (hydrogen bond)
Exendin-4 R299 ECL2 polar (charge-charge)
Exendin-4 W306 5.36x37 TM5 Van der Waals
Exendin-4 E364 6.53x53 TM6 polar (charge-charge)
Exendin-4 L384 7.39x38 TM7 Van der Waals
Exendin-4 E387 7.42x41 TM7 polar (charge-charge)
Exendin-4 L388 7.43x42 TM7 Van der Waals

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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
Helix box plot — Download: PNG | SVG V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7

GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
1x35 1.39x39 L144
1x39 1.43x43 Y148
1x43 1.47x47 Y152
TM2
2x53 2.60x60 R190
2x60 2.67x67 K197
2x64 2.71x71 L201
2x68 2.75x75 Y205
TM3
3x32 3.36x36 M233
3x33 3.37x37 Q234
3x36 3.40x40 V237
3x40 3.44x44 Y241
ECL2
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
TM6
6x48 6.53x53 E364
TM7
7x34 7.39x38 L384
7x37 7.42x41 E387
7x38 7.43x42 L388