PDB
7LLY
Resolution
3.3 Å
Released
Jan. 12, 2022
Receptor
GLP-1
Class
B1
Species
Homo sapiens
Ligand
Oxyntomodulin
Function
Agonist
Reference
10.1038/S41467-021-27760-0

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Ligand Amino Acid Generic Number Segment Interaction Type
Oxyntomodulin V36 N-term hydrophobic
Oxyntomodulin D67 N-term polar (hydrogen bond with backbone)
Oxyntomodulin D67 N-term Van der Waals
Oxyntomodulin L141 1.36x36 TM1 hydrophobic
Oxyntomodulin L141 1.36x36 TM1 Van der Waals
Oxyntomodulin L144 1.39x39 TM1 hydrophobic
Oxyntomodulin L144 1.39x39 TM1 Van der Waals
Oxyntomodulin Y145 1.40x40 TM1 hydrophobic
Oxyntomodulin Y145 1.40x40 TM1 Van der Waals
Oxyntomodulin K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
Oxyntomodulin L201 2.71x71 TM2 Van der Waals
Oxyntomodulin L201 2.71x71 TM2 hydrophobic
Oxyntomodulin Y205 2.75x75 TM2 Van der Waals
Oxyntomodulin Y205 2.75x75 TM2 polar (hydrogen bond)
Oxyntomodulin Q234 3.37x37 TM3 Van der Waals
Oxyntomodulin V237 3.40x40 TM3 Van der Waals
Oxyntomodulin V237 3.40x40 TM3 hydrophobic
Oxyntomodulin Y241 3.44x44 TM3 Van der Waals
Oxyntomodulin Y241 3.44x44 TM3 hydrophobic
Oxyntomodulin T298 45.52x52 ECL2 Van der Waals
Oxyntomodulin R299 ECL2 polar (charge-assisted hydrogen bond)
Oxyntomodulin N300 ECL2 Van der Waals
Oxyntomodulin N300 ECL2 polar (hydrogen bond)
Oxyntomodulin W306 5.36x37 TM5 Van der Waals
Oxyntomodulin W306 5.36x37 TM5 hydrophobic
Oxyntomodulin R310 5.40x40 TM5 Van der Waals
Oxyntomodulin R380 7.35x34 TM7 polar (charge-assisted hydrogen bond)
Oxyntomodulin L384 7.39x38 TM7 hydrophobic
Oxyntomodulin L384 7.39x38 TM7 Van der Waals
Oxyntomodulin E387 7.42x41 TM7 polar (charge-assisted hydrogen bond)
Oxyntomodulin L388 7.43x42 TM7 Van der Waals

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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
Helix box plot — Download: PNG | SVG V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7

GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
1x35 1.39x39 L144
1x36 1.40x40 Y145
TM2
2x60 2.67x67 K197
2x64 2.71x71 L201
2x68 2.75x75 Y205
TM3
3x33 3.37x37 Q234
3x36 3.40x40 V237
3x40 3.44x44 Y241
ECL2
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
5x44 5.40x40 R310
TM7
7x30 7.35x34 R380
7x34 7.39x38 L384
7x37 7.42x41 E387
7x38 7.43x42 L388