PDB
7M3E
Resolution
3.2 Å
Released
June 30, 2021
Receptor
CaS
Class
C
Species
Homo sapiens
Ligands
Function
NPS 2143
NAM
D-tryptophan
Co-agonist
Calcium
Agonist
Reference
10.1038/S41586-021-03691-0
NPS 2143 D-tryptophan Calcium

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
D-tryptophan R66 N-term Van der Waals
D-tryptophan W70 N-term aromatic (edge-to-face)
D-tryptophan T145 N-term hydrophobic
D-tryptophan G146 N-term Van der Waals
D-tryptophan S147 N-term polar (hydrogen bond)
D-tryptophan A168 N-term hydrophobic
D-tryptophan A168 N-term polar (hydrogen bond with backbone)
D-tryptophan S169 N-term Van der Waals
D-tryptophan S170 N-term polar (hydrogen bond)
D-tryptophan S170 N-term polar (hydrogen bond with backbone)
D-tryptophan Y218 N-term Van der Waals
Calcium D234 N-term polar (charge-charge)
D-tryptophan E297 N-term polar (charge-charge)
D-tryptophan A298 N-term Van der Waals
NPS 2143 F668 2.56x56 TM2 hydrophobic
NPS 2143 Q681 3.33x33 TM3 polar (hydrogen bond)
NPS 2143 F684 3.36x36 TM3 hydrophobic
NPS 2143 F684 3.36x36 TM3 aromatic (pi-cation)
NPS 2143 I777 5.44x44 TM5 hydrophobic
NPS 2143 F814 6.46x46 TM6 hydrophobic
NPS 2143 W818 6.50x50 TM6 hydrophobic
NPS 2143 W818 6.50x50 TM6 polar (hydrogen bond)
NPS 2143 F821 6.53x53 TM6 hydrophobic
NPS 2143 I822 6.54x54 TM6 hydrophobic
NPS 2143 Y825 6.57x57 TM6 aromatic (pi-cation)
NPS 2143 Y825 6.57x57 TM6 hydrophobic
NPS 2143 E837 7.32x33 TM7 polar (charge-charge)
NPS 2143 A840 7.35x36 TM7 hydrophobic
NPS 2143 I841 7.36x37 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 T R N P I V K A T ICL1ECL1 G E P ECL1ICL2 E A K I P T S F H R K W W ICL2ECL2 P P S S Y R N Q E L E D E I I F I T C H E G S ECL2ICL3 P E N F ICL3ECL3 Y ECL3N-term M A F Y S C C W V L L A L T W H T S A Y G P D Q R A Q K K G D I I L G G L F P I H F G V A A K D Q D L K S R P E S V E C I R Y N F R G F R W L Q A M I F A I E E I N S S P A L L P N L T L G Y R I F D T C N T V S K A L E A T L S F V A Q N K I D S L N L D E F C N C S E H I P S T I A V V G A T G S G V S T A V A N L L G L F Y I P Q V S Y A S S S R L L S N K N Q F K S F L R T I P N D E H Q A T A M A D I I E Y F R W N W V G T I A A D D D Y G R P G I E K F R E E A E E R D I C I D F S E L I S Q Y S D E E E I Q H V V E V I Q N S T A K V I V V F S S G P D L E P L I K E I V R R N I T G K I W L A S E A W A S S S L I A M P Q Y F H V V G G T I G F A L K A G Q I P G F R E F L K K V H P R K S V H N G F A K E F W E E T F N C H L Q E G A K G P L P V D T F L R G H E E S G D R F S N S S T A F R P L C T G D E N I S S V E T P Y I D Y T H L R I S Y N V Y L A V Y S I A H A L Q D I Y T C L P G R G L F T N G S C A D I K K V E A W Q V L K H L R H L N F T N N M G E Q V T F D E C G D L V G N Y S I I N W H L S P E D G S I V F K E V G Y Y N V Y A K K G E R L F I N E E K I L W S G F S R E V P F S N C S R D C L A G T R K G I I E G E P T C C F E C V E C P D G E Y S D E T D A S A C N K C P D D F W S N E N H T S C I A K E I E F L S W T N-termC-term T A A H A F K V A A R A T L R R S N V S R K R S S S L G G S T G S T P S S S I S S K S N S E D P F P Q P E R Q K Q Q Q P L A L T Q Q E Q Q Q Q P L T L P Q Q Q R S Q Q Q P R C K Q K V I F G S G T V T F S L S F D E P Q K N A M A H R N S T H Q N S L E A Q K S S D T L T R H E P L L P L Q C G E T D L D L T V Q E T G L Q G P V G G D Q R P E V E D P E E L S P A L V V S S S Q S F V I S G G G S T V T E N V V N S C-term E P F G I A L T L F A V L G I F L T A F V L G V F I K F N R E L S Y L L L F S L L C C F S S S L F F I Q D W T C R L R Q P A F G I S F V L C I S C I L V K T N R V L L V F G L N L Q F L L V F L C T F M Q I V I C V I W L Y T A L M A L G F L I G Y T C L L A A I C F F F A F K S R K L N E A K F I T F S M L I F F I V W I S F I P A Y A S T G K F V S A V E V I A I L A A S F G L L A C I F F N K I Y I I L F K P S R E V R N T I E C S
Helix box plot — Download: PNG | SVG A T L F I G L V A F L T L A I G F P E 1 Y L L L F S L L C C F S S S L F F I 2 V L I C S I C L V F S I G F A P Q R L R 3 Q F L L V F L C T F M Q I V I C V I W L 4 A F F F C I A A L L C T Y G I L F G L A 5 T F S M L I F F I V W I S F I P A Y A S 6 A L L G F S A A L I A I V E V A S V F K 7

GPCRdb(A)
GPCRdb(C)
CaS receptor
TM2
2x60 2.56x56 F668
TM3
3x29 3.33x33 Q681
3x32 3.36x36 F684
TM5
5x44 5.44x44 I777
TM6
6x44 6.46x46 F814
6x48 6.50x50 W818
6x51 6.53x53 F821
6x52 6.54x54 I822
6x55 6.57x57 Y825
TM7
7x38 7.32x33 E837
7x41 7.35x36 A840
7x42 7.36x37 I841