PDB
7MT8
Resolution
5.8 Å
Released
July 7, 2021
Receptor
Rhodopsin
Class
A
Species
Bos taurus
Ligand
Function
all-trans-retinal
Agonist
Reference
10.1038/S41586-021-03721-X

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Ligand Amino Acid Generic Number Segment Interaction Type
all-trans-retinal M86 2.53x53 TM2 Van der Waals
all-trans-retinal A117 3.32x32 TM3 hydrophobic
all-trans-retinal E122 3.37x37 TM3 Van der Waals
all-trans-retinal E181 ECL2 Van der Waals
all-trans-retinal Y191 ECL2 hydrophobic
all-trans-retinal M207 5.42x43 TM5 hydrophobic
all-trans-retinal F208 5.43x44 TM5 Van der Waals
all-trans-retinal H211 5.46x461 TM5 hydrophobic
all-trans-retinal F212 5.47x47 TM5 hydrophobic
all-trans-retinal W265 6.48x48 TM6 hydrophobic
all-trans-retinal Y268 6.51x51 TM6 hydrophobic
all-trans-retinal A269 6.52x52 TM6 hydrophobic
all-trans-retinal A272 6.55x55 TM6 hydrophobic
all-trans-retinal K296 7.43x42 TM7 covalent bond

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ICL1 K K L R ICL1ECL1 Y F V F ECL1ICL2 P M S N F R F ICL2ECL2 W S R Y I P E G M Q C S C G I D Y Y T P H E E T ECL2ICL3 Q E ICL3ECL3 Q G S D F ECL3N-term M N G T E G P N F Y V P F S N K T G V V R S P F E A P Q Y Y L A N-termC-term C G K N P L G D D E A S T T V S K T E T S Q V A P A C-term E P W Q F S M L A A Y M F L L I M L G F P I N F L T L Y V T V Q H T P L N Y I L L N L A V A D L F M V F G G F T T T L Y T S L H G G P T G C N L E G F F A T L G G E I A L W S L V V L A I E R Y V V V C K G E N H A I M G V A F T W V M A L A C A A P P L V G N N E S F V I Y M F V V H F I I P L I V I F F C Y G Q L V F T V K E A A A Q Q S A T T Q K A E K E V T R M V I I M V I A F L I C W L P Y A G V A F Y I F T H G P I F M T I P A F F A K T S A V Y N P V I Y I M M N K Q M V T F R N C T L C
Helix box plot — Download: PNG | SVG F N I P F G L M I L L F M Y A A L M S F 1 L N L A V A D L F M V G F G F T T T L Y T 2 V V L S W L A I E G G L T A F F G E L N 3 A I M G V A F T W V M A L A C A A P P L 4 Y C F F I V I L P I I F H V V F M Y I V F 5 I I M V I A F L I C W L P Y A G V A F Y 6 V P N Y V A S T K A F F A P I T M F I 7

GPCRdb(A)
GPCRdb(A)
Rhodopsin
TM2
2x53 2.53x53 M86
TM3
3x32 3.32x32 A117
3x37 3.37x37 E122
TM5
5x43 5.42x43 M207
5x44 5.43x44 F208
5x461 5.46x461 H211
5x47 5.47x47 F212
TM6
6x48 6.48x48 W265
6x51 6.51x51 Y268
6x52 6.52x52 A269
6x55 6.55x55 A272
TM7
7x42 7.43x42 K296