PDB
7MTR
Resolution
3.3 Å
Released
July 7, 2021
Receptor
mGlu2
Class
C
Species
Homo sapiens
Ligands
L-glutamic acid
ADX55164
Function
Agonist
Ago-PAM
Reference
10.1038/S41586-021-03680-3
L-glutamic acid ADX55164

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Ligand Amino Acid Generic Number Segment Interaction Type
L-glutamic acid R57 N-term polar (charge-assisted hydrogen bond)
L-glutamic acid R61 N-term polar (charge-assisted hydrogen bond)
L-glutamic acid S143 N-term polar (hydrogen bond with backbone)
L-glutamic acid S143 N-term polar (hydrogen bond)
L-glutamic acid S143 N-term Van der Waals
L-glutamic acid S145 N-term Van der Waals
L-glutamic acid S145 N-term polar (hydrogen bond)
L-glutamic acid A166 N-term Van der Waals
L-glutamic acid A166 N-term polar (hydrogen bond with backbone)
L-glutamic acid T168 N-term polar (hydrogen bond)
L-glutamic acid Y216 N-term hydrophobic
L-glutamic acid Y216 N-term Van der Waals
L-glutamic acid D295 N-term polar (charge-assisted hydrogen bond)
L-glutamic acid K377 N-term polar (charge-assisted hydrogen bond)
ADX55164 F623 2.56x56 TM2 aromatic (edge-to-face)
ADX55164 F643 3.40x40 TM3 aromatic (edge-to-face)
ADX55164 M728 5.40x40 TM5 hydrophobic
ADX55164 L732 5.44x44 TM5 hydrophobic
ADX55164 N735 5.47x47 TM5 Van der Waals
ADX55164 N735 5.47x47 TM5 polar (hydrogen bond)
ADX55164 W773 6.50x50 TM6 Van der Waals
ADX55164 W773 6.50x50 TM6 hydrophobic
ADX55164 F776 6.53x53 TM6 hydrophobic
ADX55164 F776 6.53x53 TM6 Van der Waals
ADX55164 F780 6.57x57 TM6 Van der Waals
ADX55164 F780 6.57x57 TM6 hydrophobic

NGL is a WebGL based 3D viewer powered by MMTF.

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NGL is a WebGL based 3D viewer powered by MMTF.

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Snake plot — Download: PNG | SVG
ICL1 T N A P V V K A S ICL1ECL1 K P ECL1ICL2 A R E G A Q R P R F I ICL2ECL2 A P G T G K E T A P E R R E V V T L R C N H R ECL2ICL3 P E N ICL3ECL3 S ECL3N-term M G S L L A L L A L L L L W G A V A E G P A K K V L T L E G D L V L G G L F P V H Q K G G P A E D C G P V N E H R G I Q R L E A M L F A L D R I N R D P H L L P G V R L G A H I L D S C S K D T H A L E Q A L D F V R A S L S R G A D G S R H I C P D G S Y A T H G D A P T A I T G V I G G S Y S D V S I Q V A N L L R L F Q I P Q I S Y A S T S A K L S D K S R Y D Y F A R T V P P D F F Q A K A M A E I L R F F N W T Y V S T V A S E G D Y G E T G I E A F E L E A R A R N I C V A T S E K V G R A M S R A A F E G V V R A L L Q K P S A R V A V L F T R S E D A R E L L A A S Q R L N A S F T W V A S D G W G A L E S V V A G S E G A A E G A I T I E L A S Y P I S D F A S Y F Q S L D P W N N S R N P W F R E F W E Q R F R C S F R Q R D C A A H S L R A V P F E Q E S K I M F V V N A V Y A M A H A L H N M H R A L C P N T T R L C D A M R P V N G R R L Y K D F V L N V K F D A P F R P A D T H N E V R F D R F G D G I G R Y N I F T Y L R A G S G R Y R Y Q K V G Y W A E G L T L D T S L I P W A S P S A G P L P A S R C S E P C L Q N E V K S V Q P G E V C C W L C I P C Q P Y E Y R L D E F T C A D C G L G Y W P N A S L T G C F E L P Q E Y I R W N-termC-term S R F G S A A A R A S S S L G Q G S G S Q F V P T V C N G R E V V D S T T S S L C-term G D A W A V G P V T I A C L G A L A T L F V L G V F V R H G R E L C Y I L L G G V F L C Y C M T F I F I A S T A V C T L R R L G L G T A F S V C Y S A L L T K T N R I A R I F G G S P A S Q V A I C L A L I S G Q L L I V V A W L V V E D A S M L G S L A Y N V L L I A L C T L Y A F K T R K C F N E A K F I G F T M Y T T C I I W L A F L P I F Y V T S D Y R V Q T T T M C V S V S L S G S V V L G C L F A P K L H I I L F Q P Q K H R A N V V S P T
Helix box plot — Download: PNG | SVG L T A L A G L C A I T V P G V A W A D G 1 Y I L L G G V F L C Y C M T F I F I A 2 T L L A S Y C V S F A T G L G L R R L T 3 Q V A I C L A L I S G Q L L I V V A W L 4 A Y L T C L A I L L V N Y A L S G L M S 5 G F T M Y T T C I I W L A F L P I F Y V 6 G L V V S G S L S V S V C M T T T Q V R 7

GPCRdb(A)
GPCRdb(C)
mGlu2 receptor
TM2
2x60 2.56x56 F623
TM3
3x36 3.40x40 F643
TM5
5x40 5.40x40 M728
5x44 5.44x44 L732
5x47 5.47x47 N735
TM6
6x48 6.50x50 W773
6x51 6.53x53 F776
6x55 6.57x57 F780