Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7PX4

SPECIES

Homo sapiens

RESOLUTION

2.250

PREFERRED CHAIN

A

REFERENCE

10.1002/ANIE.202115545

PUBLICATION DATE

March 2, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Preladenant conjugate PSB-2113 S67 2.65x64 TM2 Van der Waals
Preladenant conjugate PSB-2113 S67 2.65x64 TM2 polar (hydrogen bond with backbone)
Preladenant conjugate PSB-2113 T68 2.66x65 TM2 Van der Waals
Preladenant conjugate PSB-2113 L85 3.33x33 TM3 Van der Waals
Preladenant conjugate PSB-2113 L167 45.51x51 ECL2 hydrophobic
Preladenant conjugate PSB-2113 F168 45.52x52 ECL2 Van der Waals
Preladenant conjugate PSB-2113 F168 45.52x52 ECL2 hydrophobic
Preladenant conjugate PSB-2113 E169 ECL2 polar (charge-assisted hydrogen bond)
Preladenant conjugate PSB-2113 M177 5.38x40 TM5 hydrophobic
Preladenant conjugate PSB-2113 M177 5.38x40 TM5 Van der Waals
Preladenant conjugate PSB-2113 W246 6.48x48 TM6 hydrophobic
Preladenant conjugate PSB-2113 W246 6.48x48 TM6 Van der Waals
Preladenant conjugate PSB-2113 L249 6.51x51 TM6 Van der Waals
Preladenant conjugate PSB-2113 L249 6.51x51 TM6 hydrophobic
Preladenant conjugate PSB-2113 H250 6.52x52 TM6 Van der Waals
Preladenant conjugate PSB-2113 N253 6.55x55 TM6 polar (hydrogen bond)
Preladenant conjugate PSB-2113 N253 6.55x55 TM6 polar (hydrogen bond)
Preladenant conjugate PSB-2113 H264 ECL3 Van der Waals
Preladenant conjugate PSB-2113 A265 ECL3 Van der Waals
Preladenant conjugate PSB-2113 L267 7.32x31 TM7 hydrophobic
Preladenant conjugate PSB-2113 L267 7.32x31 TM7 Van der Waals
Preladenant conjugate PSB-2113 M270 7.35x34 TM7 hydrophobic
Preladenant conjugate PSB-2113 M270 7.35x34 TM7 Van der Waals
Preladenant conjugate PSB-2113 Y271 7.36x35 TM7 hydrophobic
Preladenant conjugate PSB-2113 Y271 7.36x35 TM7 Van der Waals
Preladenant conjugate PSB-2113 I274 7.39x38 TM7 Van der Waals
Preladenant conjugate PSB-2113 I274 7.39x38 TM7 hydrophobic

Ligands

Preladenant conjugate PSB-2113

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
TM2
2x64 2.65x64 S67
2x65 2.66x65 T68
TM3
3x33 3.33x33 L85
ECL2
45x51 45.51x51 L167
45x52 45.52x52 F168
TM5
5x40 5.38x40 M177
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x52 6.52x52 H250
6x55 6.55x55 N253
TM7
7x31 7.32x31 L267
7x34 7.35x34 M270
7x35 7.36x35 Y271
7x38 7.39x38 I274