PDB
7QVM
Resolution
3.3 Å
Released
Aug. 10, 2022
Receptor
OT
Class
A
Species
Homo sapiens
Ligand
oxytocin (Human)
Function
Agonist
Reference
10.1038/S41467-022-31325-0

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Ligand Amino Acid Generic Number Segment Interaction Type
oxytocin (Human) E42 1.35x35 TM1 polar (charge-assisted hydrogen bond)
oxytocin (Human) Q92 2.57x56 TM2 Van der Waals
oxytocin (Human) Q96 2.61x60 TM2 Van der Waals
oxytocin (Human) Q96 2.61x60 TM2 polar (hydrogen bond)
oxytocin (Human) D100 2.65x64 TM2 polar (charge-assisted hydrogen bond)
oxytocin (Human) K116 3.29x29 TM3 polar (charge-assisted hydrogen bond)
oxytocin (Human) Q119 3.32x32 TM3 Van der Waals
oxytocin (Human) Q171 4.60x61 TM4 polar (hydrogen bond)
oxytocin (Human) Q171 4.60x61 TM4 Van der Waals
oxytocin (Human) F175 4.64x65 TM4 hydrophobic
oxytocin (Human) F175 4.64x65 TM4 Van der Waals
oxytocin (Human) W188 45.51x51 ECL2 hydrophobic
oxytocin (Human) W188 45.51x51 ECL2 Van der Waals
oxytocin (Human) I204 5.42x43 TM5 hydrophobic
oxytocin (Human) I204 5.42x43 TM5 Van der Waals
oxytocin (Human) F291 6.51x51 TM6 Van der Waals
oxytocin (Human) F291 6.51x51 TM6 hydrophobic
oxytocin (Human) Q295 6.55x55 TM6 polar (hydrogen bond)
oxytocin (Human) Q295 6.55x55 TM6 Van der Waals
oxytocin (Human) S298 6.58x58 TM6 Van der Waals
oxytocin (Human) K306 ECL3 Van der Waals
oxytocin (Human) I312 7.36x35 TM7 Van der Waals
oxytocin (Human) I312 7.36x35 TM7 hydrophobic
oxytocin (Human) L316 7.40x39 TM7 polar (hydrogen bond with backbone)
oxytocin (Human) L316 7.40x39 TM7 Van der Waals
oxytocin (Human) A318 7.42x41 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R Q K H ICL1ECL1 R F Y G ECL1ICL2 P L R S L ICL2ECL2 S L R E V A D G V F D C W A V F I Q P ECL2ICL3 A A A E A P E G A A A G D G G R V A L A R V S S V ICL3ECL3 D A N A P ECL3N-term M E G A L A A N W S A E A A N A S A A P P G A E G N R T A G P P R R N-termC-term S Y L K G R R L G E T S A S K K S N S S S F V L S H R S S S Q R S C S Q P S T A C-term N E A L A R V E V A V L C L I L L L A L S G N A C V L L A L R T T S R L F F F M K H L S I A D L V V A V F Q V L P Q L L W D I T F P D L L C R L V K Y L Q V V G M F A S T Y L L L L M S L D R C L A I C Q R R R T D R L A V L A T W L G C L V A S A P Q V H I F W G P K A Y I T W I T L A V Y I V P V I V L A A C Y G L I S F K I W Q N L R L K T A A A K L I S K A K I R T V K M T F I I V L A F I V C W T P F F F V Q M W S V W K E A S A F I I V M L L A S L N S C C N P W I Y M L F T G H L V Q C S A L F H E R F L C
Helix box plot — Download: PNG | SVG A N G S L A L L L I L C L V A V E V R A 1 K H L S I A D L V V A F V Q V L P Q L L W 2 L L L L Y T S A F M G V V Q L Y K V L R 3 D R L A V L A T W L G C L V A S A P Q 4 Y C A A L V I V P V I Y V A L T I W T I Y 5 F I I V L A F I V C W T P F F F V Q M W 6 W P N C C S N L S A L L M V I I F A S 7

GPCRdb(A)
GPCRdb(A)
OT receptor
TM1
1x35 1.35x35 E42
TM2
2x56 2.57x56 Q92
2x60 2.61x60 Q96
2x64 2.65x64 D100
TM3
3x29 3.29x29 K116
3x32 3.32x32 Q119
TM4
4x61 4.60x61 Q171
4x65 4.64x65 F175
ECL2
45x51 45.51x51 W188
TM5
5x43 5.42x43 I204
TM6
6x51 6.51x51 F291
6x55 6.55x55 Q295
6x58 6.58x58 S298
TM7
7x35 7.36x35 I312
7x39 7.40x39 L316
7x41 7.42x41 A318