PDB
7R0C
Resolution
4.7 Å
Released
Sept. 14, 2022
Receptor
V2
Class
A
Species
Homo sapiens
Ligand
Function
vasopressin (Human)
Agonist
Reference
10.1126/SCIADV.ABO7761

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Ligand Amino Acid Generic Number Segment Interaction Type
vasopressin (Human) R32 N-term polar (hydrogen bond with backbone)
vasopressin (Human) Q92 2.57x56 TM2 Van der Waals
vasopressin (Human) Q96 2.61x60 TM2 Van der Waals
vasopressin (Human) K100 2.65x64 TM2 Van der Waals
vasopressin (Human) D103 2.68x67 TM2 Van der Waals
vasopressin (Human) Q174 4.60x61 TM4 Van der Waals
vasopressin (Human) F178 ECL2 Van der Waals
vasopressin (Human) W193 45.51x51 ECL2 hydrophobic
vasopressin (Human) A194 45.52x52 ECL2 Van der Waals
vasopressin (Human) C195 ECL2 polar (hydrogen bond with backbone)
vasopressin (Human) R202 5.35x36 TM5 polar (hydrogen bond)
vasopressin (Human) F287 6.51x51 TM6 hydrophobic
vasopressin (Human) F288 6.52x52 TM6 hydrophobic
vasopressin (Human) Q291 6.55x55 TM6 hydrophobic
vasopressin (Human) A294 6.58x58 TM6 Van der Waals
vasopressin (Human) A295 6.59x59 TM6 Van der Waals
vasopressin (Human) M311 7.39x38 TM7 hydrophobic
vasopressin (Human) L312 7.40x39 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 H W ICL1ECL1 R F R G ECL1ICL2 P M L A Y R H G ICL2ECL2 A Q R N V E G G S G V T D C W A C F A E P ECL2ICL3 P G G R R R G R R T G S P G E G ICL3ECL3 P E A P L E ECL3N-term M L M A S T T S A V P G H P S L P S L P S N S S Q E R P L D T R N-termC-term R T P P S L G P Q D E S C T T A S S S L A K D T S S C-term D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R S G A H W N R P V L V A W A F S L L L S L P Q L F I F W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S E R A H V S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D G A P F V L L M L L A S L N S C T N P W I Y A S F S S S L R S A R G V S S E L L C C
Helix box plot — Download: PNG | SVG G N S L A V A V F V I S L L A L E A R A 1 G H L C L A D L A V A F L Q V L P Q L A W 2 A L I M Y S S A Y M G V M Q L Y K V A R 3 W N R P V L V A W A F S L L L S L P Q 4 Q C A A I G L T P A V F V M L A I W T V Y 5 L V I V V V Y V L C W A P F F L V Q L W 6 W P N T C S N L S A L L M L L V F P A 7

GPCRdb(A)
GPCRdb(A)
V2 receptor
TM2
2x56 2.57x56 Q92
2x60 2.61x60 Q96
2x64 2.65x64 K100
2x67 2.68x67 D103
TM4
4x61 4.60x61 Q174
ECL2
45x51 45.51x51 W193
45x52 45.52x52 A194
TM5
5x36 5.35x36 R202
TM6
6x51 6.51x51 F287
6x52 6.52x52 F288
6x55 6.55x55 Q291
6x58 6.58x58 A294
6x59 6.59x59 A295
TM7
7x38 7.39x38 M311
7x39 7.40x39 L312