PDB
7RTB
Resolution
2.1 Å
Released
Oct. 6, 2021
Receptor
GLP-1
Class
B1
Species
Homo sapiens
Ligand
Function
Peptide-19
Agonist
Reference
10.1016/J.BBRC.2021.09.016

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Ligand Amino Acid Generic Number Segment Interaction Type
Peptide-19 T29 N-term polar (hydrogen bond with backbone)
Peptide-19 S31 N-term Van der Waals
Peptide-19 L32 N-term Van der Waals
Peptide-19 W39 N-term hydrophobic
Peptide-19 D67 N-term Van der Waals
Peptide-19 E68 N-term hydrophobic
Peptide-19 Y69 N-term hydrophobic
Peptide-19 E138 1.33x33 TM1 hydrophobic
Peptide-19 L141 1.36x36 TM1 hydrophobic
Peptide-19 L144 1.39x39 TM1 hydrophobic
Peptide-19 Y145 1.40x40 TM1 hydrophobic
Peptide-19 Y148 1.43x43 TM1 hydrophobic
Peptide-19 Y148 1.43x43 TM1 polar (hydrogen bond)
Peptide-19 R190 2.60x60 TM2 polar (charge-charge)
Peptide-19 V194 2.64x64 TM2 Van der Waals
Peptide-19 K197 2.67x67 TM2 hydrophobic
Peptide-19 K197 2.67x67 TM2 polar (hydrogen bond)
Peptide-19 K197 2.67x67 TM2 polar (charge-charge)
Peptide-19 L201 2.71x71 TM2 hydrophobic
Peptide-19 K202 2.72x72 TM2 polar (hydrogen bond)
Peptide-19 Y205 2.75x75 TM2 hydrophobic
Peptide-19 A209 2.79x79 TM2 Van der Waals
Peptide-19 Y241 3.44x44 TM3 Van der Waals
Peptide-19 R310 5.40x40 TM5 hydrophobic
Peptide-19 R310 5.40x40 TM5 polar (hydrogen bond)
Peptide-19 I313 5.43x43 TM5 hydrophobic
Peptide-19 L314 5.44x44 TM5 hydrophobic
Peptide-19 L384 7.39x38 TM7 hydrophobic
Peptide-19 E387 7.42x41 TM7 Van der Waals
Peptide-19 L388 7.43x42 TM7 hydrophobic
Peptide-19 T391 7.46x45 TM7 hydrophobic

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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
Helix box plot — Download: PNG | SVG V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7

GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x29 1.33x33 E138
1x32 1.36x36 L141
1x35 1.39x39 L144
1x36 1.40x40 Y145
1x39 1.43x43 Y148
TM2
2x53 2.60x60 R190
2x57 2.64x64 V194
2x60 2.67x67 K197
2x64 2.71x71 L201
2x65 2.72x72 K202
2x68 2.75x75 Y205
TM3
3x40 3.44x44 Y241
TM5
5x44 5.40x40 R310
5x47 5.43x43 I313
5x48 5.44x44 L314
TM7
7x34 7.39x38 L384
7x37 7.42x41 E387
7x38 7.43x42 L388
7x41 7.46x45 T391