Structure information

OT receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7RYC

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

O

REFERENCE

10.1038/S41594-022-00728-4

PUBLICATION DATE

March 9, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
oxytocin N35 1.28x28 TM1 polar (hydrogen bond with backbone)
oxytocin N35 1.28x28 TM1 Van der Waals
oxytocin L38 1.31x31 TM1 Van der Waals
oxytocin A39 1.32x32 TM1 Van der Waals
oxytocin A39 1.32x32 TM1 polar (hydrogen bond with backbone)
oxytocin Q92 2.57x56 TM2 Van der Waals
oxytocin Q96 2.61x60 TM2 polar (hydrogen bond)
oxytocin Q119 3.32x32 TM3 Van der Waals
oxytocin Q171 4.60x61 TM4 polar (hydrogen bond)
oxytocin Q171 4.60x61 TM4 Van der Waals
oxytocin F175 4.64x65 TM4 hydrophobic
oxytocin F175 4.64x65 TM4 Van der Waals
oxytocin W188 45.51x51 ECL2 hydrophobic
oxytocin W188 45.51x51 ECL2 Van der Waals
oxytocin Y200 5.38x39 TM5 hydrophobic
oxytocin I201 5.39x40 TM5 Van der Waals
oxytocin I204 5.42x43 TM5 Van der Waals
oxytocin I204 5.42x43 TM5 hydrophobic
oxytocin Q295 6.55x55 TM6 polar (hydrogen bond)
oxytocin Q295 6.55x55 TM6 Van der Waals
oxytocin V299 6.59x59 TM6 Van der Waals
oxytocin M315 7.39x38 TM7 Van der Waals
oxytocin L316 7.40x39 TM7 polar (hydrogen bond with backbone)
oxytocin L316 7.40x39 TM7 Van der Waals
oxytocin A318 7.42x41 TM7 hydrophobic
oxytocin A318 7.42x41 TM7 Van der Waals

Ligands

oxytocin

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Residue Diagrams

A N G S L A L L L I L C L V A V E V R A 1 K H L S I A D L V V A F V Q V L P Q L L W 2 L L L L Y T S A F M G V V Q L Y K V L R 3 D R L A V L A T W L G C L V A S A P Q 4 Y C A A L V I V P V I Y V A L T I W T I Y 5 F I I V L A F I V C W T P F F F V Q M W 6 W P N C C S N L S A L L M V I I F A S 7
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ICL1 R Q K H ICL1ECL1 R F Y G ECL1ICL2 P L R S L ICL2ECL2 S L R E V A D G V F D C W A V F I Q P ECL2ICL3 A A A E A P E G A A A G D G G R V A L A R V S S V ICL3ECL3 D A N A P ECL3N-term M E G A L A A N W S A E A A N A S A A P P G A E G N R T A G P P R R N-termC-term S Y L K G R R L G E T S A S K K S N S S S F V L S H R S S S Q R S C S Q P S T A C-term N E A L A R V E V A V L C L I L L L A L S G N A C V L L A L R T T S R L F F F M K H L S I A D L V V A V F Q V L P Q L L W D I T F P D L L C R L V K Y L Q V V G M F A S T Y L L L L M S L D R C L A I C Q R R R T D R L A V L A T W L G C L V A S A P Q V H I F W G P K A Y I T W I T L A V Y I V P V I V L A A C Y G L I S F K I W Q N L R L K T A A A K L I S K A K I R T V K M T F I I V L A F I V C W T P F F F V Q M W S V W K E A S A F I I V M L L A S L N S C C N P W I Y M L F T G H L V Q C S A L F H E R F L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
OT receptor
TM1
1x28 1.28x28 N35
1x31 1.31x31 L38
1x32 1.32x32 A39
TM2
2x56 2.57x56 Q92
2x60 2.61x60 Q96
TM3
3x32 3.32x32 Q119
TM4
4x61 4.60x61 Q171
4x65 4.64x65 F175
ECL2
45x51 45.51x51 W188
TM5
5x39 5.38x39 Y200
5x40 5.39x40 I201
5x43 5.42x43 I204
TM6
6x55 6.55x55 Q295
6x59 6.59x59 V299
TM7
7x38 7.39x38 M315
7x39 7.40x39 L316
7x41 7.42x41 A318