PDB
7S8P
Resolution
2.6 Å
Released
Nov. 17, 2021
Receptor
MRGPRX4
Class
A
Species
Homo sapiens
Ligand
Function
MS47134
Agonist
Reference
10.1038/S41586-021-04126-6

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Ligand Amino Acid Generic Number Segment Interaction Type
MS47134 F78 2.56x56 TM2 Van der Waals
MS47134 R82 2.60x60 TM2 polar (charge-charge)
MS47134 R82 2.60x60 TM2 aromatic (pi-cation)
MS47134 R82 2.60x60 TM2 polar (hydrogen bond)
MS47134 R82 2.60x60 TM2 hydrophobic
MS47134 R95 3.25x25 TM3 hydrophobic
MS47134 R95 3.25x25 TM3 polar (charge-charge)
MS47134 K96 3.26x26 TM3 hydrophobic
MS47134 L98 3.28x28 TM3 hydrophobic
MS47134 V99 3.29x29 TM3 hydrophobic
MS47134 M102 3.32x32 TM3 Van der Waals
MS47134 W158 ECL2 hydrophobic
MS47134 I239 ECL3 Van der Waals
MS47134 Y250 7.31x30 TM7 hydrophobic
MS47134 Y254 7.35x34 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R R ICL1ECL1 I N I ECL1ICL2 P I W Y R C R R P T ICL2ECL2 D F L F S G A ECL2ICL3 G S R K M ICL3ECL3 I Y R M H L N L E ECL3N-term M D P T V P V F G T K L T P I N G R E E T P C Y N N-termC-term Q R Q N R Q N L K L V L Q R A L Q D K P E V D K G E G Q L P E E S L E L S G S R L G P C-term Q T L S F T V L T C I I S L V G L T G N A V V L W L L G Y R M N A V S I Y I L N L A A A D F L F L S F Q I I R L P L R L S H L I R K I L V S V M T F P Y F T G L S M L S A I S T E R C L S V L W H L S A V V C V L L W G L S L L F S M L E W R F C D S S W C E T S D F I P V A W L I F L C V V L C V S S L V L L V R I L C P L T R L Y V T I L L T V L V F L L C G L P F G I L G A L V L Y C H V Y L V C M S L S S L N S S A N P I I Y F F V G S F R
Helix box plot — Download: PNG | SVG A N G T L G V L S I I C T L V T F S L T 1 L N L A A A D F L F L S F Q I I R L P L 2 A S L M S L G T F Y P F T M V S V L I K 3 S A V V C V L L W G L S L L F S M L E W 4 S S V C L V V C L F I L W A V P I F D S 5 L L T V L V F L L C G L P F G I L G A L 6 I P N A S S N L S S L S M C V L Y V H 7

GPCRdb(A)
GPCRdb(A)
MRGPRX4
TM2
2x56 2.56x56 F78
2x60 2.60x60 R82
TM3
3x25 3.25x25 R95
3x26 3.26x26 K96
3x28 3.28x28 L98
3x29 3.29x29 V99
3x32 3.32x32 M102
TM7
7x30 7.31x30 Y250
7x34 7.35x34 Y254