PDB
7SBF
Resolution
2.9 Å
Released
April 20, 2022
Receptor
μ
Class
A
Species
Mus musculus
Ligand
Function
PZM21
Agonist (partial)
Reference
10.1002/ANIE.202200269

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Ligand Amino Acid Generic Number Segment Interaction Type
PZM21 Q124 2.60x60 TM2 hydrophobic
PZM21 W133 23.50x50 ECL1 Van der Waals
PZM21 V143 3.28x28 TM3 Van der Waals
PZM21 I144 3.29x29 TM3 hydrophobic
PZM21 D147 3.32x32 TM3 hydrophobic
PZM21 D147 3.32x32 TM3 polar (hydrogen bond)
PZM21 D147 3.32x32 TM3 polar (charge-charge)
PZM21 Y148 3.33x33 TM3 aromatic (pi-cation)
PZM21 M151 3.36x36 TM3 hydrophobic
PZM21 K233 5.39x40 TM5 Van der Waals
PZM21 V236 5.42x43 TM5 hydrophobic
PZM21 W293 6.48x48 TM6 Van der Waals
PZM21 H297 6.52x52 TM6 aromatic (edge-to-face)
PZM21 V300 6.55x55 TM6 Van der Waals
PZM21 I322 7.39x38 TM7 Van der Waals
PZM21 Y326 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x60 2.60x60 Q124
ECL1
23x50 23.50x50 W133
TM3
3x28 3.28x28 V143
3x29 3.29x29 I144
3x32 3.32x32 D147
3x33 3.33x33 Y148
3x36 3.36x36 M151
TM5
5x40 5.39x40 K233
5x43 5.42x43 V236
TM6
6x48 6.48x48 W293
6x52 6.52x52 H297
6x55 6.55x55 V300
TM7
7x38 7.39x38 I322
7x42 7.43x42 Y326