PDB
7SBF
Resolution
2.9 Å
Released
April 20, 2022
Receptor
μ
Class
A
Species
Mus musculus
Ligand
PZM21
Function
Agonist (partial)
Reference
10.1002/ANIE.202200269

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Ligand Amino Acid Generic Number Segment Interaction Type
PZM21 I144 3.29x29 TM3 hydrophobic
PZM21 D147 3.32x32 TM3 polar (charge-assisted hydrogen bond)
PZM21 Y148 3.33x33 TM3 Van der Waals
PZM21 Y148 3.33x33 TM3 hydrophobic
PZM21 M151 3.36x36 TM3 hydrophobic
PZM21 M151 3.36x36 TM3 Van der Waals
PZM21 K233 5.39x40 TM5 Van der Waals
PZM21 V236 5.42x43 TM5 Van der Waals
PZM21 V236 5.42x43 TM5 hydrophobic
PZM21 V300 6.55x55 TM6 hydrophobic
PZM21 V300 6.55x55 TM6 Van der Waals
PZM21 I322 7.39x38 TM7 Van der Waals
PZM21 Y326 7.43x42 TM7 polar (hydrogen bond)

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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM3
3x29 3.29x29 I144
3x32 3.32x32 D147
3x33 3.33x33 Y148
3x36 3.36x36 M151
TM5
5x40 5.39x40 K233
5x43 5.42x43 V236
TM6
6x55 6.55x55 V300
TM7
7x38 7.39x38 I322
7x42 7.43x42 Y326