Structure information

CaS receptor

PROTEIN CLASS

Class C (Glutamate)

PDB CODE

7SIN

SPECIES

Homo sapiens

RESOLUTION

5.900

PREFERRED CHAIN

A

REFERENCE

10.1073/PNAS.2115849118

PUBLICATION DATE

Jan. 19, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
NPS 2143 R680 3.32x32 TM3 polar (charge-assisted hydrogen bond)
NPS 2143 Q681 3.33x33 TM3 polar (hydrogen bond)
NPS 2143 Q681 3.33x33 TM3 polar (hydrogen bond)
NPS 2143 Q681 3.33x33 TM3 polar (hydrogen bond)
NPS 2143 F684 3.36x36 TM3 hydrophobic
NPS 2143 F684 3.36x36 TM3 Van der Waals
NPS 2143 E767 45.52x52 ECL2 Van der Waals
NPS 2143 L770 5.37x37 TM5 Van der Waals
NPS 2143 L770 5.37x37 TM5 hydrophobic
NPS 2143 L773 5.40x40 TM5 hydrophobic
NPS 2143 L773 5.40x40 TM5 Van der Waals
NPS 2143 I777 5.44x44 TM5 hydrophobic
NPS 2143 I777 5.44x44 TM5 Van der Waals
NPS 2143 F814 6.46x46 TM6 hydrophobic
NPS 2143 F814 6.46x46 TM6 Van der Waals
NPS 2143 W818 6.50x50 TM6 hydrophobic
NPS 2143 W818 6.50x50 TM6 Van der Waals
NPS 2143 F821 6.53x53 TM6 hydrophobic
NPS 2143 F821 6.53x53 TM6 Van der Waals
NPS 2143 Y825 6.57x57 TM6 polar (hydrogen bond)
NPS 2143 Y825 6.57x57 TM6 Van der Waals
NPS 2143 E837 7.32x33 TM7 polar (charge-assisted hydrogen bond)
NPS 2143 A840 7.35x36 TM7 hydrophobic
NPS 2143 I841 7.36x37 TM7 Van der Waals
NPS 2143 I841 7.36x37 TM7 hydrophobic

Ligands

NPS 2143

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Residue Diagrams

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ICL1 T R N P I V K A T ICL1ECL1 G E P ECL1ICL2 E A K I P T S F H R K W W ICL2ECL2 P P S S Y R N Q E L E D E I I F I T C H E G S ECL2ICL3 P E N F ICL3ECL3 Y ECL3N-term M A F Y S C C W V L L A L T W H T S A Y G P D Q R A Q K K G D I I L G G L F P I H F G V A A K D Q D L K S R P E S V E C I R Y N F R G F R W L Q A M I F A I E E I N S S P A L L P N L T L G Y R I F D T C N T V S K A L E A T L S F V A Q N K I D S L N L D E F C N C S E H I P S T I A V V G A T G S G V S T A V A N L L G L F Y I P Q V S Y A S S S R L L S N K N Q F K S F L R T I P N D E H Q A T A M A D I I E Y F R W N W V G T I A A D D D Y G R P G I E K F R E E A E E R D I C I D F S E L I S Q Y S D E E E I Q H V V E V I Q N S T A K V I V V F S S G P D L E P L I K E I V R R N I T G K I W L A S E A W A S S S L I A M P Q Y F H V V G G T I G F A L K A G Q I P G F R E F L K K V H P R K S V H N G F A K E F W E E T F N C H L Q E G A K G P L P V D T F L R G H E E S G D R F S N S S T A F R P L C T G D E N I S S V E T P Y I D Y T H L R I S Y N V Y L A V Y S I A H A L Q D I Y T C L P G R G L F T N G S C A D I K K V E A W Q V L K H L R H L N F T N N M G E Q V T F D E C G D L V G N Y S I I N W H L S P E D G S I V F K E V G Y Y N V Y A K K G E R L F I N E E K I L W S G F S R E V P F S N C S R D C L A G T R K G I I E G E P T C C F E C V E C P D G E Y S D E T D A S A C N K C P D D F W S N E N H T S C I A K E I E F L S W T N-termC-term T A A H A F K V A A R A T L R R S N V S R K R S S S L G G S T G S T P S S S I S S K S N S E D P F P Q P E R Q K Q Q Q P L A L T Q Q E Q Q Q Q P L T L P Q Q Q R S Q Q Q P R C K Q K V I F G S G T V T F S L S F D E P Q K N A M A H R N S T H Q N S L E A Q K S S D T L T R H E P L L P L Q C G E T D L D L T V Q E T G L Q G P V G G D Q R P E V E D P E E L S P A L V V S S S Q S F V I S G G G S T V T E N V V N S C-term E P F G I A L T L F A V L G I F L T A F V L G V F I K F N R E L S Y L L L F S L L C C F S S S L F F I Q D W T C R L R Q P A F G I S F V L C I S C I L V K T N R V L L V F G L N L Q F L L V F L C T F M Q I V I C V I W L Y T A L M A L G F L I G Y T C L L A A I C F F F A F K S R K L N E A K F I T F S M L I F F I V W I S F I P A Y A S T G K F V S A V E V I A I L A A S F G L L A C I F F N K I Y I I L F K P S R E V R N T I E C S
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Residue Table


GPCRdb(A)
GPCRdb(C)
CaS receptor
TM3
3x28 3.32x32 R680
3x29 3.33x33 Q681
3x32 3.36x36 F684
ECL2
45x52 45.52x52 E767
TM5
5x37 5.37x37 L770
5x40 5.40x40 L773
5x44 5.44x44 I777
TM6
6x44 6.46x46 F814
6x48 6.50x50 W818
6x51 6.53x53 F821
6x55 6.57x57 Y825
TM7
7x38 7.32x33 E837
7x41 7.35x36 A840
7x42 7.36x37 I841