PDB
7SR8
Resolution
3.3 Å
Released
June 8, 2022
Receptor
OX2
Class
A
Species
Homo sapiens
Ligand
danavorexton
Function
Agonist
Reference
10.1038/S41467-022-30601-3

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Ligand Amino Acid Generic Number Segment Interaction Type
danavorexton P131 3.29x29 TM3 hydrophobic
danavorexton Q134 3.32x32 TM3 polar (hydrogen bond)
danavorexton Q134 3.32x32 TM3 polar (hydrogen bond)
danavorexton T135 3.33x33 TM3 Van der Waals
danavorexton V138 3.36x36 TM3 hydrophobic
danavorexton V138 3.36x36 TM3 Van der Waals
danavorexton F227 5.42x43 TM5 Van der Waals
danavorexton F227 5.42x43 TM5 aromatic (edge-to-face)
danavorexton Y317 6.48x48 TM6 hydrophobic
danavorexton I320 6.51x51 TM6 hydrophobic
danavorexton I320 6.51x51 TM6 Van der Waals
danavorexton N324 6.55x55 TM6 polar (hydrogen bond)
danavorexton N324 6.55x55 TM6 Van der Waals
danavorexton F346 7.35x34 TM7 Van der Waals
danavorexton H350 7.39x38 TM7 Van der Waals

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ICL1 H H M R ICL1ECL1 T W F F ECL1ICL2 P L M F K S ICL2ECL2 E C S T V F P G L A N K T T L F T V C D E R W G G E ECL2ICL3 G T S S V V Q R K W K P L Q P V S Q P R G P G Q P T K S R M S A ICL3ECL3 G M F A H T E ECL3N-term M S G T K L E D S P P C R N W S S A S E L N E T Q E P F L N P T D Y D D E E F L R Y L W R E Y L H P K E N-termC-term G V H H R Q E D R L T R G R T S T E S R K S L T T Q I S N F D N I S K L S E Q V V L T S I S T L P A A N G A G P L Q N W C-term Y E W V L I A G Y I I V F V V A L I G N V L V C V A V W K N T V T N Y F I V N L S L A D V L V T I T C L P A T L V V D I T E G Q S L C K V I P Y L Q T V S V S V S V L T L S C I A L D R W Y A I C H T A K R A R N S I V I I W I V S C I I M I P Q A I V M I Y P K M Y H I C F F L V T Y M A P L C L M V L A Y L Q I F R K L W C R Q I P V A A E I K Q I R A R R K T A R M L M I V L L V F A I C Y L P I S I L N V L K R V F D R E T V Y A W F T F S H W L V Y A N S A A N P I I Y N F L S G K F K A C C L F R E E A F S C
Helix box plot — Download: PNG | SVG V N G I L A V V F V I I Y G A I L V W E 1 V N L S L A D V L V T T I C L P A T L V V 2 C S L T L V S V S V S V T Q L Y P I V K 3 A R N S I V I I W I V S C I I M I P Q 4 Y A L V M L C L P A M Y T V L F F C I H Y 5 M I V L L V F A I C Y L P I S I L N V L 6 I P N A A S N A Y V L W H S F T F W A 7

GPCRdb(A)
GPCRdb(A)
OX2 receptor
TM3
3x29 3.29x29 P131
3x32 3.32x32 Q134
3x33 3.33x33 T135
3x36 3.36x36 V138
TM5
5x43 5.42x43 F227
TM6
6x48 6.48x48 Y317
6x51 6.51x51 I320
6x55 6.55x55 N324
TM7
7x34 7.35x34 F346
7x38 7.39x38 H350