Structure information

SST2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7T11

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

R

REFERENCE

10.1038/S41594-022-00727-5

PUBLICATION DATE

March 9, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Octreotide Q102 2.63x63 TM2 polar (hydrogen bond)
Octreotide Q102 2.63x63 TM2 Van der Waals
Octreotide D122 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Octreotide Q126 3.36x36 TM3 polar (hydrogen bond)
Octreotide I177 4.60x61 TM4 hydrophobic
Octreotide N186 ECL2 Van der Waals
Octreotide W188 ECL2 Van der Waals
Octreotide W188 ECL2 hydrophobic
Octreotide S192 ECL2 polar (hydrogen bond)
Octreotide S192 ECL2 Van der Waals
Octreotide C193 45.50x50 ECL2 Van der Waals
Octreotide T194 45.51x51 ECL2 Van der Waals
Octreotide I195 45.52x52 ECL2 Van der Waals
Octreotide W197 ECL2 Van der Waals
Octreotide Y205 5.35x36 TM5 aromatic (edge-to-face)
Octreotide Y205 5.35x36 TM5 Van der Waals
Octreotide F208 5.38x39 TM5 hydrophobic
Octreotide F208 5.38x39 TM5 Van der Waals
Octreotide I209 5.39x40 TM5 Van der Waals
Octreotide I209 5.39x40 TM5 hydrophobic
Octreotide F272 6.51x51 TM6 hydrophobic
Octreotide N276 6.55x55 TM6 Van der Waals
Octreotide N276 6.55x55 TM6 polar (hydrogen bond)
Octreotide P286 ECL3 hydrophobic
Octreotide P286 ECL3 Van der Waals
Octreotide F294 7.35x34 TM7 hydrophobic
Octreotide F294 7.35x34 TM7 Van der Waals
Octreotide Y302 7.43x42 TM7 Van der Waals

Ligands

Octreotide

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Residue Diagrams

T N G C L G I I C V V F Y I F T L V A N 1 L N L A I A D E L F M L G L P F L A M Q 2 V T L C F I S T F Q N I G D V T M V V R 3 A K M I T M A V W G V S L L V I L P I 4 Y C L C I I T L P V L F G L I F T Y I I F 5 S I V V A V F I F C W L P F Y I F N V S 6 I P N A C S N A Y T L V V V F D F M G 7
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ICL1 A K M K ICL1ECL1 V H W P F ECL1ICL2 P I K S A K W R ICL2ECL2 G L R S N Q W G R S S C T I N W P G E ECL2ICL3 G I R V G ICL3ECL3 A I S P ECL3N-term M D M A D E P L N G S H T W L S I P F D L N G S V V S T N T S N Q T E P Y Y D N-termC-term L V K V S G T D D G E R S D S K Q D K S R L N E T T E T Q R T L L N G D L Q T S I C-term L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H R P R T A K M I T M A V W G V S L L V I L P I M I Y A S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F Q N F K K S V L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
SST2 receptor
TM2
2x63 2.63x63 Q102
TM3
3x32 3.32x32 D122
3x36 3.36x36 Q126
TM4
4x61 4.60x61 I177
ECL2
45x50 45.50x50 C193
45x51 45.51x51 T194
45x52 45.52x52 I195
TM5
5x36 5.35x36 Y205
5x39 5.38x39 F208
5x40 5.39x40 I209
TM6
6x51 6.51x51 F272
6x55 6.55x55 N276
TM7
7x34 7.35x34 F294
7x42 7.43x42 Y302