PDB
7T6S
Resolution
3.0 Å
Released
March 30, 2022
Receptor
FPR2/ALX
Class
A
Species
Homo sapiens
Ligand
Function
compound 43 [PMID: 21173551]
Agonist
Reference
10.1038/S41467-022-28586-0

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Ligand Amino Acid Generic Number Segment Interaction Type
compound 43 [PMID: 21173551] L81 2.60x60 TM2 Van der Waals
compound 43 [PMID: 21173551] H102 3.29x29 TM3 Van der Waals
compound 43 [PMID: 21173551] V105 3.32x32 TM3 Van der Waals
compound 43 [PMID: 21173551] D106 3.33x33 TM3 polar (hydrogen bond)
compound 43 [PMID: 21173551] L109 3.36x36 TM3 hydrophobic
compound 43 [PMID: 21173551] F110 3.37x37 TM3 hydrophobic
compound 43 [PMID: 21173551] F110 3.37x37 TM3 aromatic (edge-to-face)
compound 43 [PMID: 21173551] V113 3.40x40 TM3 hydrophobic
compound 43 [PMID: 21173551] R201 5.38x39 TM5 polar (hydrogen bond)
compound 43 [PMID: 21173551] R205 5.42x43 TM5 hydrophobic
compound 43 [PMID: 21173551] R205 5.42x43 TM5 polar (hydrogen bond)
compound 43 [PMID: 21173551] G209 5.46x461 TM5 Van der Waals
compound 43 [PMID: 21173551] W254 6.48x48 TM6 hydrophobic
compound 43 [PMID: 21173551] F257 6.51x51 TM6 hydrophobic
compound 43 [PMID: 21173551] Q258 6.52x52 TM6 Van der Waals
compound 43 [PMID: 21173551] A261 6.55x55 TM6 Van der Waals
compound 43 [PMID: 21173551] V284 7.35x34 TM7 hydrophobic
compound 43 [PMID: 21173551] F292 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 T R ICL1ECL1 E K W P F ECL1ICL2 P V W A Q N H R ICL2ECL2 T T V T I P N G D T Y C T F N F A S W G G ECL2ICL3 M I K S ICL3ECL3 L K E M L F Y G K ECL3N-term M E T N F S T P L N E Y E E V S Y E N-termC-term P T S L E R A L S E D S A P T N D T A A N S A S P P A E T E L Q A M C-term S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H T V S L A M K V I V G P W I L A L V L T L P V F L F L T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D L I H F R E R S L
Helix box plot — Download: PNG | SVG G N G L V G L V F T V G L V V L P L I R 1 L N L A L A D F S F T A T L P F L I V S 2 F G I L F V S G F L N I D V V I H I L K 3 A M K V I V G P W I L A L V L T L P V 4 Y C I A V I S M P L S F G I V F R I I G R 5 T A V V A S F F I C W F P F Q L V A L L 6 M P N L C S N F F A L S S T P N V L I 7

GPCRdb(A)
GPCRdb(A)
FPR2/ALX
TM2
2x60 2.60x60 L81
TM3
3x29 3.29x29 H102
3x32 3.32x32 V105
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
3x40 3.40x40 V113
TM5
5x39 5.38x39 R201
5x43 5.42x43 R205
5x461 5.46x461 G209
TM6
6x48 6.48x48 W254
6x51 6.51x51 F257
6x52 6.52x52 Q258
6x55 6.55x55 A261
TM7
7x34 7.35x34 V284
7x42 7.43x42 F292