PDB
7T6V
Resolution
3.1 Å
Released
March 30, 2022
Receptor
FPR2/ALX
Class
A
Species
Homo sapiens
Ligand
Function
fMLFII
Agonist
Reference
10.1038/S41467-022-28586-0

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Ligand Amino Acid Generic Number Segment Interaction Type
fMLFII L81 2.60x60 TM2 hydrophobic
fMLFII E89 ECL1 Van der Waals
fMLFII H102 3.29x29 TM3 Van der Waals
fMLFII V105 3.32x32 TM3 hydrophobic
fMLFII D106 3.33x33 TM3 polar (hydrogen bond)
fMLFII L109 3.36x36 TM3 hydrophobic
fMLFII F110 3.37x37 TM3 hydrophobic
fMLFII V113 3.40x40 TM3 Van der Waals
fMLFII C176 45.50x50 ECL2 Van der Waals
fMLFII F178 45.52x52 ECL2 hydrophobic
fMLFII L198 5.35x36 TM5 hydrophobic
fMLFII R201 5.38x39 TM5 polar (hydrogen bond)
fMLFII R205 5.42x43 TM5 hydrophobic
fMLFII R205 5.42x43 TM5 polar (hydrogen bond)
fMLFII G209 5.46x461 TM5 Van der Waals
fMLFII W254 6.48x48 TM6 hydrophobic
fMLFII F257 6.51x51 TM6 Van der Waals
fMLFII Q258 6.52x52 TM6 Van der Waals
fMLFII A261 6.55x55 TM6 Van der Waals
fMLFII G264 6.58x58 TM6 Van der Waals
fMLFII L268 ECL3 hydrophobic
fMLFII M271 ECL3 Van der Waals
fMLFII L272 ECL3 Van der Waals
fMLFII V284 7.35x34 TM7 hydrophobic
fMLFII F292 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 T R ICL1ECL1 E K W P F ECL1ICL2 P V W A Q N H R ICL2ECL2 T T V T I P N G D T Y C T F N F A S W G G ECL2ICL3 M I K S ICL3ECL3 L K E M L F Y G K ECL3N-term M E T N F S T P L N E Y E E V S Y E N-termC-term P T S L E R A L S E D S A P T N D T A A N S A S P P A E T E L Q A M C-term S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H T V S L A M K V I V G P W I L A L V L T L P V F L F L T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D L I H F R E R S L
Helix box plot — Download: PNG | SVG G N G L V G L V F T V G L V V L P L I R 1 L N L A L A D F S F T A T L P F L I V S 2 F G I L F V S G F L N I D V V I H I L K 3 A M K V I V G P W I L A L V L T L P V 4 Y C I A V I S M P L S F G I V F R I I G R 5 T A V V A S F F I C W F P F Q L V A L L 6 M P N L C S N F F A L S S T P N V L I 7

GPCRdb(A)
GPCRdb(A)
FPR2/ALX
TM2
2x60 2.60x60 L81
TM3
3x29 3.29x29 H102
3x32 3.32x32 V105
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
3x40 3.40x40 V113
ECL2
45x50 45.50x50 C176
45x52 45.52x52 F178
TM5
5x36 5.35x36 L198
5x39 5.38x39 R201
5x43 5.42x43 R205
5x461 5.46x461 G209
TM6
6x48 6.48x48 W254
6x51 6.51x51 F257
6x52 6.52x52 Q258
6x55 6.55x55 A261
6x58 6.58x58 G264
TM7
7x34 7.35x34 V284
7x42 7.43x42 F292