PDB
7T9I
Resolution
2.9 Å
Released
Aug. 3, 2022
Receptor
TSH
Class
A
Species
Homo sapiens
Ligands
Thyrotropin subunit beta (TSH subunit beta)
Glycoprotein hormones alpha chain (TSH subunit alpha)
Function
Agonist
Agonist
Reference
10.1038/S41586-022-05159-1
Thyrotropin subunit beta (TSH subunit beta) Glycoprotein hormones alpha chain (TSH subunit alpha)

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Ligand Amino Acid Generic Number Segment Interaction Type
Thyrotropin subunit beta (TSH subunit beta) K42 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) K58 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) I60 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) I60 N-term hydrophobic
Thyrotropin subunit beta (TSH subunit beta) E61 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) R80 N-term polar (charge-assisted hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) Y82 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) Y82 N-term polar (hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) S84 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) I85 N-term polar (hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) I85 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) V87 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) H105 N-term polar (hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) R109 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) R109 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) R109 N-term polar (charge-charge)
Glycoprotein hormones alpha chain (TSH subunit alpha) N110 N-term polar (hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) N110 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) R112 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) K129 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) F130 N-term aromatic (face-to-edge)
Glycoprotein hormones alpha chain (TSH subunit alpha) F130 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) F134 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) N135 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) N135 N-term polar (hydrogen bond with backbone)
Glycoprotein hormones alpha chain (TSH subunit alpha) T136 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) G137 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) I152 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) I152 N-term polar (charge-assisted hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) F153 N-term hydrophobic
Thyrotropin subunit beta (TSH subunit beta) F153 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) F153 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) F153 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) I155 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) I155 N-term hydrophobic
Glycoprotein hormones alpha chain (TSH subunit alpha) E157 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) D160 N-term polar (hydrogen bond with backbone)
Glycoprotein hormones alpha chain (TSH subunit alpha) D160 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) P162 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) Y163 N-term Van der Waals
Glycoprotein hormones alpha chain (TSH subunit alpha) K183 N-term polar (charge-assisted hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) Y185 N-term polar (hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) Y185 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) D203 N-term polar (hydrogen bond with backbone)
Thyrotropin subunit beta (TSH subunit beta) D203 N-term polar (charge-assisted hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) D203 N-term polar (charge-charge)
Thyrotropin subunit beta (TSH subunit beta) A204 N-term hydrophobic
Thyrotropin subunit beta (TSH subunit beta) A204 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) Y206 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) N208 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) K209 N-term polar (charge-assisted hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) K209 N-term polar (charge-assisted hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) S229 N-term polar (charge-assisted hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) L230 N-term hydrophobic
Thyrotropin subunit beta (TSH subunit beta) L230 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) E251 N-term polar (charge-assisted hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) I253 N-term polar (hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) R255 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) R274 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) D276 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) G294 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) L296 N-term hydrophobic
Thyrotropin subunit beta (TSH subunit beta) L296 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) E297 N-term polar (hydrogen bond with backbone)
Thyrotropin subunit beta (TSH subunit beta) E297 N-term polar (charge-assisted hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) F381 N-term polar (hydrogen bond)
Glycoprotein hormones alpha chain (TSH subunit alpha) D382 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) Y385 N-term polar (hydrogen bond)
Thyrotropin subunit beta (TSH subunit beta) T388 N-term Van der Waals
Thyrotropin subunit beta (TSH subunit beta) I389 N-term hydrophobic
Thyrotropin subunit beta (TSH subunit beta) I389 N-term Van der Waals

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NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 H Y K L N ICL1ECL1 H S E Y Y N H A I D W Q T ECL1ICL2 A M R L D R K I ICL2ECL2 I S S Y A K V S I C L P M D T E ECL2ICL3 P Q Y N ICL3ECL3 K P L I T ECL3N-term M R P A D L L Q L V L L L D L P R D L G G M G C S S P P C E C H Q E E D F R V T C K D I Q R I P S L P P S T Q T L K L I E T H L R T I P S H A F S N L P N I S R I Y V S I D V T L Q Q L E S H S F Y N L S K V T H I E I R N T R N L T Y I D P D A L K E L P L L K F L G I F N T G L K M F P D L T K V Y S T D I F F I L E I T D N P Y M T S I P V N A F Q G L C N E T L T L K L Y N N G F T S V Q G Y A F N G T K L D A V Y L N K N K Y L T V I D K D A F G G V Y S G P S L L D V S Q T S V T A L P S K G L E H L K E L I A R N T W T L K K L P L S L S F L H L T R A D L S Y P S H C C A F K N Q K K I R G I L E S L M C N E S S M Q S L R Q R K S V N A L N S P L H Q E Y E E N L G D S I V G Y K E K S K F Q D T H N N A H Y Y V F F E E Q E D E I I G F G Q E L K N P Q E E T L Q A F D S H Y D Y T I C G D S E D M V C T P K S D E F N P C E D I M G N-termC-term G I C K R Q A Q A Y R G Q R V P P K N S T D I Q V Q K V T H D M R Q G L H N M E D V Y E L I E N S H L T P K K Q G Q I S E E Y M Q T V L C-term Y K F L R I V V W F V S L L A L L G N V F V L L I L L T S V P R F L M C N L A F A D F C M G M Y L L L I A S V D L Y T G P G C N T A G F F T V F A S E L S V Y T L T V I T L E R W Y A I T F R L R H A C A I M V G G W V C C F L L A L L P L V G T P L A L A Y I V F V L T L N I V A F V I V C C C Y V K I Y I T V R N P G D K D T K I A K R M A V L I F T D F I C M A P I S F Y A L S A I L N V S N S K I L L V L F Y P L N S C A N P F L Y A I F T K A V F I F F Q R D L L S K
Helix box plot — Download: PNG | SVG V N G L L A L L S V F W V V I R L F K Y 1 C N L A F A D F C M G M Y L L L I A S V 2 V T L T Y V S L E S A F V T F F G A T N 3 A C A I M V G G W V C C F L L A L L P L 4 Y C C C V I V F A V I N L T L V F V I Y 5 A V L I F T D F I C M A P I S F Y A L S 6 F P N A C S N L P Y F L V L L I K S N 7

GPCRdb(A)
GPCRdb(A)
TSH receptor