PDB
7TRK
Resolution
2.8 Å
Released
May 17, 2023
Receptor
M4
Class
A
Species
Homo sapiens
Ligand
Function
iperoxo
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
iperoxo D112 3.32x32 TM3 polar (charge-charge)
iperoxo Y113 3.33x33 TM3 aromatic (pi-cation)
iperoxo Y113 3.33x33 TM3 hydrophobic
iperoxo S116 3.36x36 TM3 Van der Waals
iperoxo N117 3.37x37 TM3 Van der Waals
iperoxo V120 3.40x40 TM3 hydrophobic
iperoxo W164 4.57x57 TM4 Van der Waals
iperoxo A203 5.46x461 TM5 Van der Waals
iperoxo F204 5.47x47 TM5 Van der Waals
iperoxo W413 6.48x48 TM6 hydrophobic
iperoxo Y416 6.51x51 TM6 aromatic (pi-cation)
iperoxo Y416 6.51x51 TM6 hydrophobic
iperoxo N417 6.52x52 TM6 Van der Waals
iperoxo Y439 7.39x38 TM7 aromatic (pi-cation)
iperoxo C442 7.42x41 TM7 Van der Waals
iperoxo Y443 7.43x42 TM7 Van der Waals

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ICL1 R Q L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P A R R ICL2ECL2 K R T V P D N Q C F I Q F L S ECL2ICL3 G P K E K K A K T L A F L K S P L M K Q S V K K P P P G E A A R E E L R N G K L E E A P P P A L P P P P R P V A D K D T S N E S S S G S A T Q N T K E R P A T E L S T T E A T T P A M P A P P L Q P R A L N P A S R W S K I Q I V T K Q T G N E C V T A I E I V P A T P A G M R P A A N V A R K F A S I A R N Q V R K K ICL3ECL3 Q S C I ECL3N-term M A N F T P V N G S S G N Q S V R L V T S S S H N N-termC-term Y R N I G T A R C-term R Y E T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V H K H R P E R Q M A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F R H Q F K K T L L L C
Helix box plot — Download: PNG | SVG I N G V V T V L S L S G T V T A I F V M 1 F S L A C A D L I I G F A S M N L Y T V Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G L M I A A A W V L S F V L W A P A I 4 Y L V T M I V V P L Y F A A I A T G F T V 5 F A I L L A F I L T W T P Y N V M V L V 6 A P N I T S N V Y C L W Y G I S W V T 7

GPCRdb(A)
GPCRdb(A)
M4 receptor
TM3
3x32 3.32x32 D112
3x33 3.33x33 Y113
3x36 3.36x36 S116
3x37 3.37x37 N117
3x40 3.40x40 V120
TM4
4x57 4.57x57 W164
TM5
5x461 5.46x461 A203
5x47 5.47x47 F204
TM6
6x48 6.48x48 W413
6x51 6.51x51 Y416
6x52 6.52x52 N417
TM7
7x38 7.39x38 Y439
7x41 7.42x41 C442
7x42 7.43x42 Y443