PDB
7TRQ
Resolution
2.5 Å
Released
May 17, 2023
Receptor
M4
Class
A
Species
Homo sapiens
Ligands
VU0467154
iperoxo
Function
PAM
Agonist
Reference
—
VU0467154 iperoxo

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Ligand Amino Acid Generic Number Segment Interaction Type
VU0467154 Y89 2.61x60 TM2 Van der Waals
VU0467154 Y89 2.61x60 TM2 polar (hydrogen bond)
VU0467154 Y92 2.64x63 TM2 Van der Waals
VU0467154 Y92 2.64x63 TM2 hydrophobic
VU0467154 I93 2.65x64 TM2 polar (hydrogen bond with backbone)
VU0467154 I93 2.65x64 TM2 Van der Waals
VU0467154 G96 2.68x67 TM2 Van der Waals
iperoxo Y113 3.33x33 TM3 hydrophobic
iperoxo V120 3.40x40 TM3 hydrophobic
VU0467154 Q184 ECL2 polar (hydrogen bond)
VU0467154 Q184 ECL2 polar (hydrogen bond)
VU0467154 F186 45.51x51 ECL2 aromatic (face-to-face)
VU0467154 F186 45.51x51 ECL2 Van der Waals
VU0467154 L190 ECL2 Van der Waals
VU0467154 L190 ECL2 hydrophobic
iperoxo A203 5.46x461 TM5 hydrophobic
iperoxo W413 6.48x48 TM6 hydrophobic
iperoxo Y416 6.51x51 TM6 hydrophobic
iperoxo N417 6.52x52 TM6 Van der Waals
iperoxo N417 6.52x52 TM6 polar (hydrogen bond)
VU0467154 D432 7.32x31 TM7 polar (charge-assisted hydrogen bond)
VU0467154 T433 7.33x32 TM7 Van der Waals
VU0467154 T433 7.33x32 TM7 polar (hydrogen bond)
VU0467154 W435 7.35x34 TM7 Van der Waals
VU0467154 W435 7.35x34 TM7 aromatic (face-to-face)
VU0467154 S436 7.36x35 TM7 Van der Waals
iperoxo Y439 7.39x38 TM7 Van der Waals
iperoxo Y439 7.39x38 TM7 hydrophobic
VU0467154 Y439 7.39x38 TM7 Van der Waals
iperoxo C442 7.42x41 TM7 Van der Waals
iperoxo C442 7.42x41 TM7 hydrophobic
iperoxo Y443 7.43x42 TM7 Van der Waals
iperoxo Y443 7.43x42 TM7 hydrophobic

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NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 R Q L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P A R R ICL2ECL2 K R T V P D N Q C F I Q F L S ECL2ICL3 G P K E K K A K T L A F L K S P L M K Q S V K K P P P G E A A R E E L R N G K L E E A P P P A L P P P P R P V A D K D T S N E S S S G S A T Q N T K E R P A T E L S T T E A T T P A M P A P P L Q P R A L N P A S R W S K I Q I V T K Q T G N E C V T A I E I V P A T P A G M R P A A N V A R K F A S I A R N Q V R K K ICL3ECL3 Q S C I ECL3N-term M A N F T P V N G S S G N Q S V R L V T S S S H N N-termC-term Y R N I G T A R C-term R Y E T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V H K H R P E R Q M A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F R H Q F K K T L L L C
Helix box plot — Download: PNG | SVG I N G V V T V L S L S G T V T A I F V M 1 F S L A C A D L I I G F A S M N L Y T V Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G L M I A A A W V L S F V L W A P A I 4 Y L V T M I V V P L Y F A A I A T G F T V 5 F A I L L A F I L T W T P Y N V M V L V 6 A P N I T S N V Y C L W Y G I S W V T 7

GPCRdb(A)
GPCRdb(A)
M4 receptor
TM2
2x60 2.61x60 Y89
2x63 2.64x63 Y92
2x64 2.65x64 I93
2x67 2.68x67 G96
TM3
3x33 3.33x33 Y113
3x40 3.40x40 V120
ECL2
45x51 45.51x51 F186
TM5
5x461 5.46x461 A203
TM6
6x48 6.48x48 W413
6x51 6.51x51 Y416
6x52 6.52x52 N417
TM7
7x31 7.32x31 D432
7x32 7.33x32 T433
7x34 7.35x34 W435
7x35 7.36x35 S436
7x38 7.39x38 Y439
7x41 7.42x41 C442
7x42 7.43x42 Y443