PDB
7TRS
Resolution
2.8 Å
Released
May 17, 2023
Receptor
M4
Class
A
Species
Homo sapiens
Ligand
Function
acetylcholine
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
acetylcholine D112 3.32x32 TM3 polar (charge-charge)
acetylcholine Y113 3.33x33 TM3 aromatic (pi-cation)
acetylcholine S116 3.36x36 TM3 Van der Waals
acetylcholine N117 3.37x37 TM3 Van der Waals
acetylcholine W164 4.57x57 TM4 hydrophobic
acetylcholine A203 5.46x461 TM5 hydrophobic
acetylcholine W413 6.48x48 TM6 aromatic (pi-cation)
acetylcholine W413 6.48x48 TM6 hydrophobic
acetylcholine Y416 6.51x51 TM6 hydrophobic
acetylcholine Y416 6.51x51 TM6 aromatic (pi-cation)
acetylcholine Y439 7.39x38 TM7 aromatic (pi-cation)
acetylcholine C442 7.42x41 TM7 Van der Waals
acetylcholine Y443 7.43x42 TM7 Van der Waals

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ICL1 R Q L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P A R R ICL2ECL2 K R T V P D N Q C F I Q F L S ECL2ICL3 G P K E K K A K T L A F L K S P L M K Q S V K K P P P G E A A R E E L R N G K L E E A P P P A L P P P P R P V A D K D T S N E S S S G S A T Q N T K E R P A T E L S T T E A T T P A M P A P P L Q P R A L N P A S R W S K I Q I V T K Q T G N E C V T A I E I V P A T P A G M R P A A N V A R K F A S I A R N Q V R K K ICL3ECL3 Q S C I ECL3N-term M A N F T P V N G S S G N Q S V R L V T S S S H N N-termC-term Y R N I G T A R C-term R Y E T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V H K H R P E R Q M A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F R H Q F K K T L L L C
Helix box plot — Download: PNG | SVG I N G V V T V L S L S G T V T A I F V M 1 F S L A C A D L I I G F A S M N L Y T V Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G L M I A A A W V L S F V L W A P A I 4 Y L V T M I V V P L Y F A A I A T G F T V 5 F A I L L A F I L T W T P Y N V M V L V 6 A P N I T S N V Y C L W Y G I S W V T 7

GPCRdb(A)
GPCRdb(A)
M4 receptor
TM3
3x32 3.32x32 D112
3x33 3.33x33 Y113
3x36 3.36x36 S116
3x37 3.37x37 N117
TM4
4x57 4.57x57 W164
TM5
5x461 5.46x461 A203
TM6
6x48 6.48x48 W413
6x51 6.51x51 Y416
TM7
7x38 7.39x38 Y439
7x41 7.42x41 C442
7x42 7.43x42 Y443