PDB
7TRY
Resolution
3.7 Å
Released
Nov. 9, 2022
Receptor
CRF2
Class
B1
Species
Homo sapiens
Ligand
Function
CHEMBL427807
Agonist
Reference
10.1038/S41467-022-33851-3

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL427807 F68 N-term hydrophobic
CHEMBL427807 I93 N-term Van der Waals
CHEMBL427807 Y95 N-term hydrophobic
CHEMBL427807 P100 N-term hydrophobic
CHEMBL427807 L169 2.67x67 TM2 hydrophobic
CHEMBL427807 H174 ECL1 hydrophobic
CHEMBL427807 F256 45.52x52 ECL2 polar (hydrogen bond with backbone)
CHEMBL427807 F256 45.52x52 ECL2 hydrophobic
CHEMBL427807 G257 ECL2 Van der Waals
CHEMBL427807 K258 ECL2 Van der Waals
CHEMBL427807 Q269 5.40x40 TM5 hydrophobic
CHEMBL427807 I272 5.43x43 TM5 Van der Waals
CHEMBL427807 L276 5.47x47 TM5 Van der Waals
CHEMBL427807 Y323 6.53x53 TM6 hydrophobic
CHEMBL427807 F326 ECL3 Van der Waals
CHEMBL427807 V328 ECL3 hydrophobic
CHEMBL427807 F340 7.38x37 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R S I R ICL1ECL1 D H E V H E S N ECL1ICL2 T Y S T E R L ICL2ECL2 N E Q C W F G K E P G D L ECL2ICL3 S T T ICL3ECL3 N P G E D ECL3N-term M D A A L L H S L L E A N C S L A L A E E L L L D G W G P P L D P E G P Y S Y C N T T L D Q I G T C W P R S A A G A L V E R P C P E Y F N G V K Y N T T R N A Y R E C L E N G T W A S K I N Y S Q C E N-termC-term R A M S I P T S P T R I S F H S I K Q T A A V C-term P I L D D K Q R K Y D L H Y R I A L V V N Y L G H C V S V A A L V A A F L L F L A L C L R N V I H W N L I T T F I L R N V M W F L L Q L V E V W C R C I T T I F N Y F V V T N F F W M F V E G C Y L H T A I V M R K C L F L F I G W C I P F P I I V A W A I G K L Y Y E V D Y I Y Q G P I I L V L L I N F V F L F N I V R I L M T K L R A S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V D L S Q I M F I Y F N S F L Q S F Q G F F V S V F Y C F F N G E V R K W Q D R V P V R S A R W H R H H S L M A
Helix box plot — Download: PNG | SVG V L A A V S V C H G L Y N V V L A I R Y 1 W N L I T T F I L R N V M W F L L Q L V 2 V F M W F F N T V V F Y N F I T T I C R 3 R K C L F L F G I W C I P F P I I V A W A 4 L F V F N I L L V L I I P G Q Y I Y D V 5 L V L L P L L G I T Y M L F F V 6 V S V F F G Q F S Q L F S N F Y I F M 7

GPCRdb(A)
GPCRdb(B)
CRF2 receptor
TM2
2x60 2.67x67 L169
ECL2
45x52 45.52x52 F256
TM5
5x44 5.40x40 Q269
5x47 5.43x43 I272
5x51 5.47x47 L276
TM6
6x48 6.53x53 Y323
TM7
7x33 7.38x37 F340