PDB
7TUZ
Resolution
3.1 Å
Released
April 13, 2022
Receptor
GPR183
Class
A
Species
Homo sapiens
Ligand
7α,25-dihydroxycholesterol
Function
Agonist
Reference
10.1016/J.STR.2022.04.006

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Ligand Amino Acid Generic Number Segment Interaction Type
7α,25-dihydroxycholesterol Y112 3.33x33 TM3 polar (hydrogen bond)
7α,25-dihydroxycholesterol Y116 3.37x37 TM3 polar (hydrogen bond)
7α,25-dihydroxycholesterol Q162 4.56x56 TM4 Van der Waals
7α,25-dihydroxycholesterol Y184 ECL2 hydrophobic
7α,25-dihydroxycholesterol Y184 ECL2 Van der Waals
7α,25-dihydroxycholesterol L197 5.39x40 TM5 Van der Waals
7α,25-dihydroxycholesterol A200 5.42x43 TM5 hydrophobic
7α,25-dihydroxycholesterol A200 5.42x43 TM5 Van der Waals
7α,25-dihydroxycholesterol Y260 6.51x51 TM6 Van der Waals
7α,25-dihydroxycholesterol L290 7.35x34 TM7 hydrophobic
7α,25-dihydroxycholesterol V294 7.39x38 TM7 hydrophobic

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ICL1 R K K I ICL1ECL1 F D W R I ECL1ICL2 P L R Y N K I K ICL2ECL2 M S K Q E A E R I T C M E Y P N F E E T K ECL2ICL3 P L T E K S ICL3ECL3 S N F L E C ECL3N-term M D I Q M A N N F T P P S A T P Q G N D C D L Y A N-termC-term Q V S V S I S S A V K S A P E E N S R E M T E T Q M M I H S K S S N G K C-term H H S T A R I V M P L H Y S L V F I I G L V G N L L A L V V I V Q N N S T T L Y S T N L V I S D I L F T T A L P T R I A Y Y A M G G D A L C R I T A L V F Y I N T Y A G V N F M T C L S I D R F I A V V H R I E H A K G V C I F V W I L V F A Q T L P L L I N P S L P W I L L G A C F I G Y V L P L I I I L I C Y S Q I C C K L F R T A K Q N G V N K K A L N T I I L I I V V F V L C F T P Y H V A I I Q H M I K K L R F S Q R H S F Q I S L H F T V C L M N F N C C M D P F I Y F F A C K G V M R Y K R K M L K R
Helix box plot — Download: PNG | SVG L N G V L G I I F V L S Y H L P M V I R 1 T N L V I S D I L F T T A L P T R I A Y 2 C T M F N V G A Y T N I Y F V L A T I R 3 A K G V C I F V W I L V F A Q T L P L 4 Y C I L I I I L P L V Y G I F C A G L L I 5 I L I I V V F V L C F T P Y H V A I I Q 6 F P D M C C N F N M L C V T F H L S I 7

GPCRdb(A)
GPCRdb(A)
GPR183
TM3
3x33 3.33x33 Y112
3x37 3.37x37 Y116
TM4
4x56 4.56x56 Q162
TM5
5x40 5.39x40 L197
5x43 5.42x43 A200
TM6
6x51 6.51x51 Y260
TM7
7x34 7.35x34 L290
7x38 7.39x38 V294