PDB
7TYI
Resolution
3.3 Å
Released
March 30, 2022
Receptor
CT
Class
B1
Species
Homo sapiens
Ligand
Islet amyloid polypeptide
Function
Agonist
Reference
10.1126/SCIENCE.ABM9609

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Ligand Amino Acid Generic Number Segment Interaction Type
Islet amyloid polypeptide W79 N-term aromatic (face-to-edge)
Islet amyloid polypeptide F99 N-term hydrophobic
Islet amyloid polypeptide P100 N-term Van der Waals
Islet amyloid polypeptide P100 N-term polar (hydrogen bond with backbone)
Islet amyloid polypeptide D101 N-term polar (charge-assisted hydrogen bond)
Islet amyloid polypeptide F102 N-term hydrophobic
Islet amyloid polypeptide F102 N-term Van der Waals
Islet amyloid polypeptide H121 N-term Van der Waals
Islet amyloid polypeptide W128 N-term polar (hydrogen bond)
Islet amyloid polypeptide W128 N-term Van der Waals
Islet amyloid polypeptide S129 N-term Van der Waals
Islet amyloid polypeptide S129 N-term polar (hydrogen bond with backbone)
Islet amyloid polypeptide Y131 N-term Van der Waals
Islet amyloid polypeptide Y131 N-term hydrophobic
Islet amyloid polypeptide T132 N-term Van der Waals
Islet amyloid polypeptide F137 N-term aromatic (edge-to-face)
Islet amyloid polypeptide F137 N-term Van der Waals
Islet amyloid polypeptide K141 1.32x32 TM1 Van der Waals
Islet amyloid polypeptide L142 1.33x33 TM1 hydrophobic
Islet amyloid polypeptide L142 1.33x33 TM1 Van der Waals
Islet amyloid polypeptide A145 1.36x36 TM1 hydrophobic
Islet amyloid polypeptide A145 1.36x36 TM1 Van der Waals
Islet amyloid polypeptide Y146 1.37x37 TM1 polar (hydrogen bond)
Islet amyloid polypeptide Y146 1.37x37 TM1 Van der Waals
Islet amyloid polypeptide L148 1.39x39 TM1 Van der Waals
Islet amyloid polypeptide L148 1.39x39 TM1 hydrophobic
Islet amyloid polypeptide V206 ECL1 polar (hydrogen bond with backbone)
Islet amyloid polypeptide V206 ECL1 Van der Waals
Islet amyloid polypeptide G209 ECL1 Van der Waals
Islet amyloid polypeptide V212 ECL1 hydrophobic
Islet amyloid polypeptide V212 ECL1 Van der Waals
Islet amyloid polypeptide R213 ECL1 polar (charge-assisted hydrogen bond)
Islet amyloid polypeptide H226 3.36x36 TM3 polar (hydrogen bond)
Islet amyloid polypeptide Q227 3.37x37 TM3 polar (hydrogen bond)
Islet amyloid polypeptide Y234 3.44x44 TM3 hydrophobic
Islet amyloid polypeptide N288 ECL2 Van der Waals
Islet amyloid polypeptide L291 45.52x52 ECL2 Van der Waals
Islet amyloid polypeptide L291 45.52x52 ECL2 polar (hydrogen bond with backbone)
Islet amyloid polypeptide S292 ECL2 Van der Waals
Islet amyloid polypeptide V293 ECL2 polar (hydrogen bond with backbone)
Islet amyloid polypeptide V293 ECL2 Van der Waals
Islet amyloid polypeptide E294 ECL2 polar (hydrogen bond with backbone)
Islet amyloid polypeptide E294 ECL2 Van der Waals
Islet amyloid polypeptide H296 ECL2 polar (hydrogen bond)
Islet amyloid polypeptide L298 5.36x37 TM5 Van der Waals
Islet amyloid polypeptide Y299 5.37x38 TM5 polar (hydrogen bond)
Islet amyloid polypeptide Y299 5.37x38 TM5 Van der Waals
Islet amyloid polypeptide H302 5.40x40 TM5 Van der Waals
Islet amyloid polypeptide H302 5.40x40 TM5 polar (hydrogen bond)
Islet amyloid polypeptide M306 5.44x44 TM5 Van der Waals
Islet amyloid polypeptide F356 6.53x53 TM6 hydrophobic
Islet amyloid polypeptide F356 6.53x53 TM6 Van der Waals
Islet amyloid polypeptide P360 ECL3 polar (hydrogen bond with backbone)
Islet amyloid polypeptide P360 ECL3 Van der Waals
Islet amyloid polypeptide H377 7.43x42 TM7 Van der Waals
Islet amyloid polypeptide I380 7.46x45 TM7 Van der Waals
Islet amyloid polypeptide H381 7.47x46 TM7 Van der Waals

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ICL1 R S L G ICL1ECL1 V P N G E L V R R D ECL1ICL2 A V F T E K Q ICL2ECL2 N D N C W L S V E T H L ECL2ICL3 E ICL3ECL3 R P S ECL3N-term M R F T F T S R C L A L F L L L N H P T P I L P A F S N Q T Y P T I E P K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y N-termC-term P S N R S A R A A A A A A E A G D I P I Y I C H Q E L R N E P A N N Q G E E S A E I I P L N I I E Q E S S A C-term T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V K R F K I R W G V Q T T Q W A Q Q W N Q R R
Helix box plot — Download: PNG | SVG V L T F I S L S H G V I A L Y Y L V Y A 1 K N M F L T Y I L N S M I I I I H L V E 2 C L M W F Y N C A M M Y Q H F F H L I K 3 R L R W Y Y L G L W G F P L V P T T I H A 4 L F F F N V V L A A M V P G H I I Y L 5 M I L V P L L G I Q F V V F P W 6 T A V F F G Q F H I L S H M V Y D Y I 7

GPCRdb(A)
GPCRdb(B)
CT receptor
TM1
1x28 1.32x32 K141
1x29 1.33x33 L142
1x32 1.36x36 A145
1x33 1.37x37 Y146
1x35 1.39x39 L148
TM3
3x32 3.36x36 H226
3x33 3.37x37 Q227
3x40 3.44x44 Y234
ECL2
45x52 45.52x52 L291
TM5
5x41 5.36x37 L298
5x42 5.37x38 Y299
5x44 5.40x40 H302
5x48 5.44x44 M306
TM6
6x48 6.53x53 F356
TM7
7x38 7.43x42 H377
7x41 7.46x45 I380
7x42 7.47x46 H381