PDB
7U2K
Resolution
3.3 Å
Released
Dec. 7, 2022
Receptor
μ
Class
A
Species
Mus musculus
Ligand
Function
CHEMBL147044
Agonist
Reference
10.1038/S41586-022-05588-Y

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL147044 D114 2.50x50 TM2 polar (charge-charge)
CHEMBL147044 A117 2.53x53 TM2 Van der Waals
CHEMBL147044 Q124 2.60x60 TM2 Van der Waals
CHEMBL147044 V143 3.28x28 TM3 hydrophobic
CHEMBL147044 I144 3.29x29 TM3 hydrophobic
CHEMBL147044 D147 3.32x32 TM3 polar (charge-charge)
CHEMBL147044 Y148 3.33x33 TM3 hydrophobic
CHEMBL147044 N150 3.35x35 TM3 Van der Waals
CHEMBL147044 M151 3.36x36 TM3 Van der Waals
CHEMBL147044 S154 3.39x39 TM3 Van der Waals
CHEMBL147044 C217 45.50x50 ECL2 Van der Waals
CHEMBL147044 W293 6.48x48 TM6 Van der Waals
CHEMBL147044 I296 6.51x51 TM6 Van der Waals
CHEMBL147044 H297 6.52x52 TM6 Van der Waals
CHEMBL147044 I322 7.39x38 TM7 hydrophobic
CHEMBL147044 G325 7.42x41 TM7 Van der Waals
CHEMBL147044 Y326 7.43x42 TM7 hydrophobic
CHEMBL147044 S329 7.46x46 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x50 2.50x50 D114
2x53 2.53x53 A117
2x60 2.60x60 Q124
TM3
3x28 3.28x28 V143
3x29 3.29x29 I144
3x32 3.32x32 D147
3x33 3.33x33 Y148
3x35 3.35x35 N150
3x36 3.36x36 M151
3x39 3.39x39 S154
ECL2
45x50 45.50x50 C217
TM6
6x48 6.48x48 W293
6x51 6.51x51 I296
6x52 6.52x52 H297
TM7
7x38 7.39x38 I322
7x41 7.42x41 G325
7x42 7.43x42 Y326
7x46 7.46x46 S329