PDB
7U2L
Resolution
3.2 Å
Released
May 4, 2022
Receptor
μ
Class
A
Species
Mus musculus
Ligand
Function
C5 guano
Agonist
Reference
10.1038/S41586-022-05588-Y

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Ligand Amino Acid Generic Number Segment Interaction Type
C5 guano D114 2.50x50 TM2 polar (charge-charge)
C5 guano A117 2.53x53 TM2 Van der Waals
C5 guano Q124 2.60x60 TM2 hydrophobic
C5 guano N127 2.63x63 TM2 Van der Waals
C5 guano W133 23.50x50 ECL1 hydrophobic
C5 guano W133 23.50x50 ECL1 aromatic (edge-to-face)
C5 guano V143 3.28x28 TM3 hydrophobic
C5 guano I144 3.29x29 TM3 hydrophobic
C5 guano D147 3.32x32 TM3 polar (hydrogen bond)
C5 guano D147 3.32x32 TM3 polar (charge-charge)
C5 guano Y148 3.33x33 TM3 hydrophobic
C5 guano N150 3.35x35 TM3 Van der Waals
C5 guano M151 3.36x36 TM3 Van der Waals
C5 guano W293 6.48x48 TM6 hydrophobic
C5 guano I296 6.51x51 TM6 hydrophobic
C5 guano H297 6.52x52 TM6 Van der Waals
C5 guano V300 6.55x55 TM6 hydrophobic
C5 guano I322 7.39x38 TM7 hydrophobic
C5 guano G325 7.42x41 TM7 polar (hydrogen bond with backbone)
C5 guano Y326 7.43x42 TM7 hydrophobic
C5 guano S329 7.46x46 TM7 Van der Waals

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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x50 2.50x50 D114
2x53 2.53x53 A117
2x60 2.60x60 Q124
2x63 2.63x63 N127
ECL1
23x50 23.50x50 W133
TM3
3x28 3.28x28 V143
3x29 3.29x29 I144
3x32 3.32x32 D147
3x33 3.33x33 Y148
3x35 3.35x35 N150
3x36 3.36x36 M151
TM6
6x48 6.48x48 W293
6x51 6.51x51 I296
6x52 6.52x52 H297
6x55 6.55x55 V300
TM7
7x38 7.39x38 I322
7x41 7.42x41 G325
7x42 7.43x42 Y326
7x46 7.46x46 S329