PDB
7UL3
Resolution
3.0 Å
Released
June 29, 2022
Receptor
H2
Class
A
Species
Homo sapiens
Ligand
Function
famotidine
Antagonist
Reference
10.1038/S41594-022-00859-8

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Ligand Amino Acid Generic Number Segment Interaction Type
famotidine D98 3.32x32 TM3 polar (hydrogen bond)
famotidine V99 3.33x33 TM3 Van der Waals
famotidine C102 3.36x36 TM3 Van der Waals
famotidine T103 3.37x37 TM3 polar (hydrogen bond)
famotidine K175 45.51x51 ECL2 Van der Waals
famotidine V176 45.52x52 ECL2 polar (hydrogen bond with backbone)
famotidine V176 45.52x52 ECL2 hydrophobic
famotidine D186 5.42x43 TM5 Van der Waals
famotidine T190 5.46x461 TM5 Van der Waals
famotidine W247 6.48x48 TM6 Van der Waals
famotidine Y250 6.51x51 TM6 hydrophobic
famotidine Y250 6.51x51 TM6 polar (hydrogen bond)
famotidine F254 6.55x55 TM6 Van der Waals
famotidine L274 7.39x38 TM7 hydrophobic
famotidine Y278 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R R L R ICL1ECL1 K W S F ECL1ICL2 P L R Y P V L V ICL2ECL2 W N S R N E T S K G N H T T S K C K V Q V ECL2ICL3 H I S ICL3ECL3 G D D A I ECL3N-term M A P N G T A S S N-termC-term C R L A N R N S H K T S L R S N A S Q L S R T Q S R E P R Q Q E E K P L K L Q V W S G T E V T A P Q G A T D R C-term F C L D S T A C K I T I T V V L A V L I L I T V A G N V V V C L A V G L N N L T N C F I V S L A I T D L L L G L L V L P F S A I Y Q L S C G K V F C N I Y T S L D V M L C T A S I L N L F M I S L D R Y C A V M D T P V R V A I S L V L I W V I S I T L S F L S I H L G N E V Y G L V D G L V T F Y L P L L I M C I T Y Y R I F K V A R D Q A K R I N S W K A A T I R E H K A T V T L A A V M G A F I I C W F P Y F T A F V Y R G L R N E V L E A I V L W L G Y A N S A L N P I L Y A A L N R D Y Q Q F R T G L F C
Helix box plot — Download: PNG | SVG V N G A V T I L I L V A L V V T I T I K 1 V S L A I T D L L L G L L V L P F S A I Y 2 M F L N L I S A T C L M V D L S T Y I N 3 V A I S L V L I W V I S I T L S F L S I 4 Y T I C M I L L P L Y F T V L G D V L G Y 5 A A V M G A F I I C W F P Y F T A F V Y 6 I P N L A S N A Y G L W L V I A E L V 7

GPCRdb(A)
GPCRdb(A)
H2 receptor
TM3
3x32 3.32x32 D98
3x33 3.33x33 V99
3x36 3.36x36 C102
3x37 3.37x37 T103
ECL2
45x51 45.51x51 K175
45x52 45.52x52 V176
TM5
5x43 5.42x43 D186
5x461 5.46x461 T190
TM6
6x48 6.48x48 W247
6x51 6.51x51 Y250
6x55 6.55x55 F254
TM7
7x38 7.39x38 L274
7x42 7.43x42 Y278