Structure information

μ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7UL4

SPECIES

Mus musculus

RESOLUTION

2.800

PREFERRED CHAIN

A

REFERENCE

10.1038/S41594-022-00859-8

PUBLICATION DATE

June 29, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
alvimopan W133 23.50x50 ECL1 hydrophobic
alvimopan D147 3.32x32 TM3 polar (charge-assisted hydrogen bond)
alvimopan M151 3.36x36 TM3 hydrophobic
alvimopan M151 3.36x36 TM3 Van der Waals
alvimopan L219 45.52x52 ECL2 Van der Waals
alvimopan V236 5.42x43 TM5 Van der Waals
alvimopan I296 6.51x51 TM6 hydrophobic
alvimopan I296 6.51x51 TM6 Van der Waals
alvimopan H297 6.52x52 TM6 aromatic (face-to-edge)
alvimopan V300 6.55x55 TM6 hydrophobic
alvimopan V300 6.55x55 TM6 Van der Waals
alvimopan I322 7.39x38 TM7 hydrophobic
alvimopan Y326 7.43x42 TM7 Van der Waals

Ligands

alvimopan

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Residue Diagrams

F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7
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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
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Residue Table


GPCRdb(A)
GPCRdb(A)
μ receptor
ECL1
23x50 23.50x50 W133
TM3
3x32 3.32x32 D147
3x36 3.36x36 M151
ECL2
45x52 45.52x52 L219
TM5
5x43 5.42x43 V236
TM6
6x51 6.51x51 I296
6x52 6.52x52 H297
6x55 6.55x55 V300
TM7
7x38 7.39x38 I322
7x42 7.43x42 Y326